A behavioral trial for parents of childhood cancer survivors with neurobehavioral

针对患有神经行为的儿童癌症幸存者父母的行为试验

• 批准号: 7489261
• 负责人: Sunita K Patel
• 金额: $ 8.33万
• 依托单位: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-18 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7489261
• 关键词: Address; Adherence; Behavior; Behavioral; Cancer Survivor; Caregivers; Caring; Central Nervous System Diseases; Child; Clinic; Cognitive; Control Groups; Cranial Irradiation; Data; Diagnosis; Educational Intervention; Exercise; Frequencies; Functional disorder; Home environment; Intervention; Intrathecal Chemotherapy; Investigation; Knowledge; Late Effects; Learning; Malignant Childhood Neoplasm; Malignant Neoplasms; Manuals; Measures; NIH Program Announcements; Neuraxis; Neurocognitive; Numbers; Outcome; Parenting behavior; Parents; Performance; Pilot Projects; Purpose; Randomized Controlled Trials; Rate; Research; Risk; Route; Schools; Score; Stress; Survivors; Telephone; Testing; Therapeutic; Therapeutic Intervention; Time; Training; Waiting Lists; base; childhood cancer survivor; design; improved; innovation; interest; intervention program; neurobehavioral; programs; remediation; response; size; skills; skills training; success; teacher

DESCRIPTION (provided by applicant): More than 50% of children diagnosed with cancer are at risk for adverse neurocognitive changes due to central nervous system (CNS) disease and/or CNS directed therapy, such as cranial radiation and intrathecal chemotherapy. While there are a large number of studies to identify and quantify the adverse neurobehavioral impact of childhood cancer, empirical investigations of therapeutic interventions to treat such sequelae are only now emerging. The current proposed study, in response to a Program Announcement for quality of cancer survival, represents an important step in advancing the research to improve and manage neurocognitive and behavioral late effects in childhood cancer survivors with CNS-directed therapy. The study is innovative in that it diverges from the recent, child directed remediation efforts based in the clinic, which thus far have yielded limited and only small benefits, and instead explores the potential of a different route to positively influence child outcomes. The study pilots a behavioral trial to empirically evaluate the impact of a parent intervention for the primary purpose of improving the child's academic, cognitive, and behavioral functioning. We have developed a training manual for our parent intervention that addresses four basic parenting components important to promote learning and school success in the child. We will evaluate the feasibility of implementing our program, track adherence, and collect preliminary data on the impact. Project Relevance: This study is expected to increase knowledge about whether specific parenting activities may positively impact learning and school performance in children treated with CNS-directed therapy and who have neurocognitive and behavioral/adaptive difficulties.

描述（由申请人提供）：超过50%被诊断患有癌症的儿童由于中枢神经系统（CNS）疾病和/或中枢神经系统定向治疗（如颅放射和鞘内化疗）而有不良神经认知改变的风险。虽然有大量的研究来确定和量化儿童癌症的不良神经行为影响，但治疗这种后遗症的治疗干预的实证研究现在才出现。目前提出的研究，响应癌症生存质量的项目公告，代表了推进研究的重要一步，以改善和管理神经认知和行为对儿童癌症幸存者的中枢神经系统定向治疗的晚期效应。这项研究的创新之处在于，它不同于最近在诊所开展的以儿童为导向的补救措施，这些措施迄今为止只产生了有限的、很小的好处，而是探索了一种不同途径对儿童结果产生积极影响的潜力。该研究引导了一项行为试验，以经验评估父母干预的影响，主要目的是改善孩子的学业、认知和行为功能。我们为我们的家长干预制定了一份培训手册，其中阐述了四个基本的养育要素，这些要素对促进孩子的学习和学业成功很重要。我们将评估实施计划的可行性，跟踪遵守情况，并收集影响的初步数据。项目相关性：本研究旨在增加关于特定的父母活动是否会对接受中枢神经系统定向治疗的儿童的学习和学校表现产生积极影响的知识，这些儿童有神经认知和行为/适应困难。