Abubakar;Pwani;Adolescent Executive Functioning Association with Scholastic Outcomes, Risk Taking Behavior and Medical Adherence in the Context of HIV

Abubakar;Pwani;艾滋病毒背景下青少年执行功能与学业成绩、冒险行为和医疗依从性的关系

• 批准号: MR/M025454/1
• 负责人: Charles Newton
• 金额: $ 96.62万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FM025454%2F1
• 关键词: Abubakar; Pwani; Adolescent; Executive; Functioning

Children born HIV positive are living longer due to the availability of Antiretroviral (ARVs). However, to realize their full potential these children need to receive interventions that reduce the negative impact of HIV. In Africa, there is limited research evidence to guide the development of these much needed intervention programmes. I propose to study the impact of HIV exposure on the functioning of adolescents aged 10-14 years at the Kenyan Coast. A total of 552 (184 HIV infected, 184 HIV exposed uninfected and 184 unexposed randomly selected from the community) adolescents aged 10-14 years shall be recruited. A longitudinal study design will be used. Each subject will be assessed thrice, within a 24 months period with 12 months between each assessment. We will use direct psychological assessment complemented by parental report and will statistically analyse the data to identify the nature and antecedents of HIV-related impairments. Identifying sources of poor neuropsychological outcomes will provide information on useful points of intervention.

由于抗逆转录病毒药物的可用性，出生时艾滋病毒阳性的儿童寿命更长。然而，为了充分发挥这些儿童的潜力，他们需要接受减少艾滋病毒负面影响的干预措施。在非洲，指导制定这些急需的干预方案的研究证据有限。我建议研究艾滋病毒暴露对肯尼亚海岸10-14岁青少年功能的影响。总共将招募552名10-14岁的青少年（184名感染艾滋病毒，184名未感染艾滋病毒，184名未感染艾滋病毒，从社区中随机抽取）。将采用纵向研究设计。每个受试者将在24个月内进行三次评估，每次评估之间间隔12个月。我们将采用直接的心理评估和父母报告相辅相成的方法，并对数据进行统计分析，以确定艾滋病毒相关损伤的性质和成因。确定不良神经心理学结果的来源将提供有用干预点的信息。

项目成果

Economic burden and mental health of primary caregivers of perinatally HIV infected adolescents from Kilifi, Kenya

肯尼亚基利菲围产期艾滋病毒感染青少年主要照顾者的经济负担和心理健康

• DOI: 10.21203/rs.2.17246/v2
• 发表时间: 2020
• 作者: Katana P

Layered vulnerability and researchers' responsibilities: Learning from research involving Kenyan adolescents living with perinatal HIV infection

分层脆弱性和研究人员的责任：从涉及围产期艾滋病毒感染的肯尼亚青少年的研究中学习

• DOI: 10.21203/rs.3.rs-1358459/v1
• 发表时间: 2022
• 作者: Kimani M

Screening tools for HIV-associated neurocognitive disorders among adults living with HIV in sub-Saharan Africa: A scoping review.

撒哈拉以南非洲艾滋病毒感染者中与艾滋病毒相关的神经认知障碍的筛查工具：范围界定审查。

• DOI: 10.12688/aasopenres.12921.2
• 发表时间: 2018
• 期刊: AAS open research
• 作者: Mwangala PN

Cognition, mood and quality-of-life outcomes among low literacy adults living with epilepsy in rural Kenya: A preliminary study.

• DOI: 10.1016/j.yebeh.2018.05.032
• 发表时间: 2018-08
• 期刊: Epilepsy & behavior : E&B
• 作者: Mwangala PN;Kariuki SM;Nyongesa MK;Mwangi P;Chongwo E;Newton CR;Abubakar A
• 通讯作者: Abubakar A

Validation of a Swahili version of the World Health Organization 5-item well-being index among adults living with HIV and epilepsy in rural coastal Kenya.

• DOI: 10.1186/s41256-018-0081-z
• 发表时间: 2018
• 期刊: Global health research and policy
• 影响因子: 8.7
• 作者: Chongwo E;Ssewanyana D;Nasambu C;Mwangala PN;Mwangi PM;Nyongesa MK;Newton CR;Abubakar A
• 通讯作者: Abubakar A