Effects of Personal Exposure to Volatile Organic Compounds on Liver Function

描述(申请人提供)：摘要：接触挥发性有机化合物(VOCs)在日常生活中普遍存在。准确评估挥发性有机化合物对公众健康构成的风险，既需要在全人口的基础上量化这些暴露，也需要评估与不同暴露水平相关的潜在健康影响。我们所做的初步分析表明，在NHANES III数据中，选定的VOCs的血液水平与肝功能异常测试之间存在关联。我们建议使用NHANES 1999-2000的数据，对个人接触VOCs对肝功能的潜在影响进行彻底的检查。我们将调查是否有独立的影响，或者这些影响是否被酒精消费和止痛药的使用所改变。此外，在将毒理上相似的VOCs分组后，我们将检查暴露于一组VOCs与肝功能生化标记物之间的关联。根据10个VOC的个人监测数据描述VOC暴露状态。肝功能生化指标包括血清白蛋白、胆红素、丙氨酸氨基转移酶、天冬氨酸氨基转移酶、乳酸脱氢酶、碱性磷酸酶和3-谷氨酰转移酶。这些生物标志物的水平将通过不同的暴露水平进行比较。多元线性回归和Logistic模型将被用来检验是否存在线性关联或阈值效应，这只在相对较高的暴露水平发生。还将对分组进行分析。通过检查肝功能敏感标志物与个人暴露监测数据的关系，这项拟议的研究能够在相对较低的暴露水平下检测VOCs的微妙/亚临床效应。对挥发性有机化合物暴露与酒精消费和药物使用之间可能相互作用的评估可能有助于确定易感亚群。如果确定了背景VOC暴露对肝功能的影响，则可以使用调节来减少所涉及的暴露。如果证实无症状人群的肝酶升高与环境中暴露于挥发性有机化合物有关，这一发现将对个人和公众健康都非常有用。叙述我们建议使用NHANES 1999-2000的数据，对个人接触VOCs对肝功能的潜在影响进行彻底的检查。通过检查肝功能敏感标志物与个体暴露监测数据的关系，这项拟议的研究可能能够在相对较低的暴露水平检测到VOCs的微妙影响。如果确定了背景暴露对肝功能的影响，则可以使用调节来减少所涉及的暴露。

DESCRIPTION (provided by applicant): Abstract: Exposure to volatile organic compounds (VOCs) occurs commonly in everyday life. Accurate assessment of the risk to public health posed by VOCs requires both the quantification of these exposures on a population-wide basis and the evaluation of potential health effects associated with varying exposure levels. Preliminary analyses that we have done show that in the NHANES III data an association exists between blood levels of selected VOCs and abnormal liver function tests. We propose to conduct a thorough examination of the potential effects of personal exposure to VOCs on liver function, using the data from NHANES 1999-2000. We will investigate whether there are independent effects or if the effects are modified by alcohol consumption and use of pain medications. In addition, we will examine the associations between exposure to a cluster of VOCs and biochemical markers of liver function after grouping toxicologically similar VOCs. VOC exposure status will be described according to the personal monitoring data for ten VOCs. Biochemical markers of liver function included serum concentrations of albumin, bilirubin, alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, alkaline phosphatase, and 3-glutamyl transferase. Levels of these biomarkers will be compared by different exposure levels. Multiple linear regression and logistic models will be used to examine whether there is a linear association or a threshold effect which occurs only at relatively high levels of exposure. The analyses will also be performed for subgroups. By examining the relationship of sensitive markers of liver function and individual exposure monitoring data in a large national sample, this proposed study is able to detect a subtle/subclinical effect of VOCs at relatively low exposure levels. The assessment of possible interactions of VOC exposure with alcohol consumption and medication use may help to identify susceptible subgroups. If the effect of background VOC exposure on liver function is identified, then regulation can be used to reduce the exposures implicated. If it is confirmed that liver-enzyme elevations in asymptomatic people are linked with environmental exposure to volatile organic compounds, the finding will be very useful to both individual and public health. Narrative We propose to conduct a thorough examination of the potential effects of personal exposure to VOCs on liver function, using the data from NHANES 1999-2000. By examining the relationship of sensitive markers of liver function and individual exposure monitoring data, this proposed study may be able to detect a subtle effect of VOCs at relatively low exposure levels. If the effect of background exposure on liver function is identified, then regulation can be used to reduce the exposures implicated.