Examination of the relationships between environmental exposures to volatile organic compounds and biochemical liver tests: application of canonical correlation analysis.
Examination of the relationships between environmental exposures to volatile organic compounds and biochemical liver tests: application of canonical correlation analysis.
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DOI：
10.1016/j.envres.2008.11.002
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发表时间：
2009-02
影响因子：
8.3
通讯作者：
Wu, Tiejian
中科院分区：
文献类型：
--
作者：
Liu, Jing;Drane, Wanzer;Liu, Xuefeng;Wu, Tiejian
本研究应用典型相关分析探讨十种挥发性有机物（VOCs）暴露与肝脏生化指标的关系。使用了1999-2000年全国健康和营养检查调查的子样本数据。血清白蛋白、总胆红素（TB）、丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、乳酸脱氢酶（LDH）、碱性磷酸酶（ALP）和γ-谷氨酰转移酶（GGT）作为结局变量。通过使用研究参与者佩戴的被动暴露监测器评估了苯、氯仿、三氯甲烷、四氯乙烯、甲苯、三氯乙烯、邻二甲苯、间二甲苯、对二甲苯、1，4-二氯苯和甲基叔丁基醚（MTBE）的个人暴露。前两个典型相关系数分别为0.3218和0.2575，说明主要是6种挥发性有机物之间的正相关（苯、二甲苯、甲苯、邻二甲苯、间二甲苯、对二甲苯和甲基叔丁基醚）和三项生化肝脏检查（白蛋白，ALP和GGT）和主要在两种VOC之间呈正相关（1，4-二氯苯和四氯乙烯）和两项生化肝脏试验（LDH和TB）。随后的多元线性回归显示，暴露于苯，甲苯，或甲基叔丁基醚与血清白蛋白，而暴露于四氯乙烯与LDH和总胆红素。总之，暴露于某些挥发性有机化合物作为一个群体或单独可能会影响某些生化肝脏测试结果在一般人群。
This study was to explore the relationships between personal exposure to ten volatile organic compounds (VOCs) and biochemical liver tests with the application of canonical correlation analysis. Data from a subsample of the 1999–2000 National Health and Nutrition Examination Survey were used. Serum albumin, total bilirubin (TB), alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), and γ-glutamyl transferase (GGT) served as the outcome variables. Personal exposures to benzene, chloroform, ethylbenzene, tetrachloroethene, toluene, trichloroethene, o-xylene, m-, p-xylene, 1,4-dichlorobenzene, and methyl tert-butyl ether (MTBE) were assessed through the use of passive exposure monitors worn by study participants. The first two canonical correlations were 0.3218 and 0.2575, suggesting a positive correlation mainly between the six VOCs (benzene, ethylbenzene, toluene, o-xylene, m-, p-xylene, and MTBE) and the three biochemical liver tests (albumin, ALP, and GGT) and a positive correlation mainly between the two VOCs (1,4-dichlorobenzene and tetrachloroethene) and the two biochemical liver tests (LDH and TB). Subsequent multiple linear regressions show that exposure to benzene, toluene, or MTBE was associated with serum albumin, while exposure to tetrachloroethene was associated with LDH and total bilirubin. In conclusion, exposure to certain VOCs as a group or individually may influence certain biochemical liver test results in the general population.
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DOI：
10.1007/s00420-003-0476-z
发表时间：
2004-01-01
影响因子：
3
作者：
Kaukiainen, A;Vehmas, T;Taskinen, H
通讯作者：
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影响因子：
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作者：
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DOI：
10.1038/sj.jes.7500635
发表时间：
2008-07-01
影响因子：
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作者：
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通讯作者：
Rappaport, S. M.
影响因子：
105.7
作者：
Kim, HC;Nam, CM;Suh, I
通讯作者：
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影响因子：
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作者：
REES, D;SODERLUND, N;MYERS, J
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