Emerging Trends of Tryptamine Use: Contexts & Risks

描述(由申请者提供)：国家药物滥用研究所优先研究“俱乐部毒品”，如摇头丸、氯胺酮和甲基苯丙胺。在最近一波俱乐部吸毒浪潮之后，出现了其他毒品趋势，包括色胺的使用增加。色胺包括广泛的天然化合物和合成化合物。许多色胺具有致幻性质，包括DMT、AMT、DIPT及其类似物5-Meo-DMT、5-Meo-AMT和5-Meo-DIPT。这些物质已经被亚马逊的土著部落使用了几个世纪，通常用于萨满仪式。用于萨满仪式的最常见的色胺是DMT，它是阿瓦斯卡的有效成分。最近，色胺--更具体地说是合成色胺--已经成为美国年轻人滥用的毒品。DEA要求对其中几种物质进行紧急调度，因为这些药物的使用被视为“一个新出现的问题”(DEA，2003)。近年来，这些物质的销售和分销已导致全国不同地区的逮捕。虽然这些物质在美国许多州都出现了，但缺乏对这些物质的基本社会和行为研究。很明显，这些物质的使用正在发生，但除了这一事实之外，我们对这些物质知之甚少。这项拨款申请提出了一项关于这类物质的探索性研究，在行为科学文献中存在很大差距。这项拟议的研究将有助于在美国就色胺使用的新趋势制定行为研究议程。我们的目标是为教育和预防工作提供有用的数据。这项拟议研究的具体目的是对纽约大都会地区周围青年亚文化中的年轻人使用色胺进行描述性的人种学研究。我们打算收集关于纽约市大都会地区45名年轻人开始和随后使用的模式、做法和背景的数据。这笔赠款的具体重点将是针对与色胺使用有关的亚文化场景中的青年，以便我们在这些物质可能扩散到青年消费的一般模式之前了解它们。

DESCRIPTION (provided by applicant): The National Institutes on Drug Abuse has prioritized research on "club drugs," such as ecstasy, ketamine, and methamphetamine. On the heels of the recent wave of club drug use, other drug trends emerged including an increase in tryptamine use. Tryptamines include a broad range of naturally-occurring and synthetic compounds. Many of the tryptamines are of a hallucinogenic nature, including DMT, AMT, DIPT and their analogues 5-Meo-DMT, 5-Meo-AMT, and 5-Meo-DIPT. These substances have been used by indigenous tribes of the Amazon for centuries, commonly used for shamanic rituals. The most familiar tryptamine used for shamanic rituals is DMT, the active ingredient in ayahuasca. More recently, tryptamines - more specifically synthetic tryptamines - have become drugs of abuse among youth and young adults in the United States. The DEA requested emergency scheduling on several of these substances because the use of these drugs is viewed as "an emerging problem" (DEA, 2003). In recent years, the sale and distribution of these substances has resulted in arrests in various regions across the country. Though emergent throughout many states in the nation, basic social and behavioral research on these substances is lacking. It is clear that the use of these substances is occurring, but we know little about these substances beyond that fact. This grant application proposes an exploratory study of this class of substances on which there exists large gaps in the behavioral sciences literature. The proposed study will assist with the development of a behavioral research agenda in the United States on the emerging trend of tryptamine use. Our goal is to provide data useful for education and prevention efforts. The specific purpose of the proposed study is to conduct a descriptive ethnographic study of tryptamine use among young adults in youth subcultures around the New York metropolitan area. We intend to gather data on the patterns, practices, and contexts of initiation and subsequent episodes of use among 45 young adults in the New York City metropolitan area. The specific focus of this grant will be to target youth involved in subcultural scenes associated with tryptamine use such that we may understand these substances before they potentially diffuse to general patterns of youth consumption.