Ten Year Longitudinal Analyses/Risk for Dental Caries in HIV Seropositive Women

艾滋病毒血清阳性女性的十年纵向分析/龋齿风险

• 批准号: 7391312
• 负责人: Stefanie L Russell
• 金额: $ 7.61万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7391312
• 关键词: Accounting; Adherence; Adverse effects; Affect; Behavior; Behavioral; CD4 Lymphocyte Count; CD4/CD8 ratio procedure; Caring; Clinical; Cocaine; Cohort Studies; Collection; Data; Data Quality; Databases; Demographic Factors; Dental; Dental Care; Dental Hygiene; Dental caries; Development; Disadvantaged; Disease; Drug usage; Education; Epidemiologist; Ethnic Origin; Factor Analysis; Frequencies; Gingival Recession; Goals; Grant; HIV; HIV Infections; Health; Highly Active Antiretroviral Therapy; Illicit Drugs; Incidence; Income; Individual; Injection of therapeutic agent; Interview; Investigation; Low income; Matched Group; Measurement; Medical; Methamphetamine; Methodology; Minority; Minority Groups; Nature; Oral; Oral health; Outcome; Parents; Participant; Pattern; Personal Satisfaction; Persons; Pharmaceutical Preparations; Plant Roots; Preventive; Provider; Public Health; Race; Rate; Recruitment Activity; Research; Research Personnel; Research Project Grants; Resources; Risk; Risk Factors; Root Caries; Saliva; Salivary; Secondary to; Self Care; Services; Severity of illness; Smoking; Social Welfare; Standards of Weights and Measures; Statistical Data Interpretation; Surface; Time; Tooth Diseases; Treatment Protocols; United States; Viral Load result; Woman; disorder risk; follow-up; oral HIV; patient home care; prospective; response; size

DESCRIPTION (provided by applicant): It is well-established that dental caries (dental decay), one the most prevalent diseases in the United States, tends to disproportionably affect racial and ethnic minorities, and those who are economically and socially disadvantaged, and those with underlying medical problems. HIV+ persons are likely to be ethnic/racial minorities and are likely to be socio-economically disadvantaged, compared to HIV- persons. A recent 5-year investigation found that HIV infection was related to dental caries, but reasons for the disparity were unclear, and, perhaps most importantly, risk factors for caries within the HIV+ persons were not well defined as a result of this study. The objective of this proposed investigation is to clarify the relationship between HIV infection and dental caries. The Women's Interagency HIV Study (WIHS) and its oral sub-study (WIHS-OS) represent one of the largest studied cohorts of HIV+ persons in the United States, and provide the largest collection medical, interview and dental data of HIV+ persons followed for an extended period of time, beginning in 1995 and ending only recently (November, 2004). As part of the WIHS-OS, 844, primarily minority, women (719 HIV+, 125 HIV-) were recruited from the parent WIHS core in 1995-96; in 2001/02, in order to investigate the effects of HIV medications on a variety of outcomes, an additional 173 HIV+ women were added, for a total of 1017 women. Participants had interviews, medical and dental exams every six months. We propose to examine, using standard and appropriate statistical methodologies, using the WIHS and the WIHS-OS, whether demographic factors (income, education, race/ethnicity, drug use), behavioral factors (smoking, illicit drug use, use of dental services and oral self-care), HIV disease severity, HIV medication use, and oral health factors (saliva, oral hygiene and gum disease) are related to the development of caries over ten years. These proposed analyses are different from analyses that have been previously done because they will include data collected over the entire 10-year period of observation, from all women in the WIHS-OS and because they will include analysis of factors that have not previously been examined in this group. These analyses provide the best opportunity to resolve currently unanswered questions regarding the nature of caries in HIV+ persons, given the size of the database, the long, prospective nature of the follow-up for dental caries, and the high quality of the data. The results of these analyses will provide greatly needed clinical, practical, and public health information to dental and medical providers, as well as to those persons and agencies that are indebted to caring for the medical, dental and social welfare of persons with HIV infection. Recent studies have found that HIV infection may predispose persons to the development of dental decay (caries) due to side effects from medications and because of health damaging and health promoting behaviors in HIV+ persons. This proposed study is relevant because will resolve currently unanswered questions regarding the nature of caries in HIV+ persons. The results of these analyses will provide greatly needed clinical, practical, and public health information to dental and medical providers, as well as to those persons and agencies that are indebted to caring for the medical, dental and social welfare of persons with HIV infection.

描述（由申请人提供）：众所周知，龋齿（蛀牙）是美国最普遍的疾病之一，往往不成比例地影响种族和少数民族，以及经济和社会上处于不利地位的人，以及有潜在医疗问题的人。与艾滋病毒感染者相比，艾滋病毒阳性者可能是少数民族/种族，并且可能处于社会经济不利地位。最近一项为期5年的调查发现，HIV感染与龋齿有关，但差异的原因尚不清楚，也许最重要的是，由于这项研究的结果，HIV+人群中龋齿的危险因素没有得到很好的定义。本研究的目的是阐明HIV感染与龋齿之间的关系。妇女机构间艾滋病毒研究（WIHS）及其口腔子研究（WIHS- os）是美国最大的艾滋病毒感染者研究群体之一，提供了从1995年开始到最近（2004年11月）的长期艾滋病毒感染者的最大的医疗、访谈和牙科数据收集。作为WIHS- os的一部分，1995- 1996年从父母的WIHS核心中招募了844名妇女，主要是少数民族妇女（719名HIV+， 125名HIV-）；2001/02年度，为了调查艾滋病毒药物对各种结果的影响，又增加了173名艾滋病毒阳性妇女，使妇女总数达到1017名。参与者每六个月进行一次面谈、医疗和牙科检查。我们建议使用标准和适当的统计方法，使用WIHS和WIHS- os，检查人口因素（收入，教育，种族/民族，药物使用），行为因素（吸烟，非法药物使用，使用牙科服务和口腔自我保健），HIV疾病严重程度，HIV药物使用和口腔健康因素（唾液，口腔卫生和牙龈疾病）是否与十年来的龋齿发展有关。这些拟议的分析不同于以前所做的分析，因为它们将包括整个10年观察期间收集的数据，来自WIHS-OS中的所有妇女，并且因为它们将包括以前未在该组中检查的因素的分析。考虑到数据库的规模、龋齿随访的长期、前瞻性以及数据的高质量，这些分析为解决目前有关HIV+患者龋齿性质的未解问题提供了最佳机会。这些分析的结果将为牙科和医疗提供者以及那些有义务照顾艾滋病毒感染者的医疗、牙科和社会福利的个人和机构提供急需的临床、实用和公共卫生信息。最近的研究发现，由于药物的副作用以及艾滋病毒感染者的健康损害和健康促进行为，艾滋病毒感染可能使人易患蛀牙（龋齿）。这项拟议的研究是相关的，因为它将解决目前尚未解决的关于HIV+人群龋齿性质的问题。这些分析的结果将为牙科和医疗提供者以及那些有义务照顾艾滋病毒感染者的医疗、牙科和社会福利的个人和机构提供急需的临床、实用和公共卫生信息。