CORE--CLINICAL

临床服务核心的目标是支持一系列研究可能与精神分裂症病因相关的临床表型和内表型的项目。具体地说，我们将研究1)一系列接受治疗的首发精神分裂症患者；2)作为精神对照组的首发非精神分裂症患者；3)首发精神分裂症患者的成年一级家庭成员；4)精神分裂症患者及其相关精神障碍高危青少年的后代；以及5)与患者及其亲属来自同一社区的健康对照对象。为了实现这些目标，临床服务核心将招募研究对象，并使用包括实验室和神经放射评估在内的综合诊断和精神病理学评估单元来确定研究对象的特征。将对患者进行六个月的跟踪调查，以确定诊断的稳定性。所有数据都将储存在由统计和数据管理核心D管理的数据库中，中心调查人员可查阅这些数据。CORE还将为脑库CORE-B配备工作人员并举行案例会议，以实现对所有死后死亡病例的共识诊断 取脑标本。来自临床服务核心的数据将被用来测试项目7-卡特和通过其他机制资助的相关项目中关于精神分裂症病因生理学的具体假设。

The goal of the Clinical Services Core is to support a range of projects that examine the clinical phenotypes and the endophenotypes that may be associated with the etiopathogenesis of schizophrenia. Specifically, we will study 1) a series of treatment-naive, first-episode schizophrenia patients; 2) first-episode non-schizophrenia psychotic subjects as a psychiatric comparison group; 3) adult first-degree family members of the first-episode schizophrenia patients; 4) adolescent offspring of schizophrenia patients at high risk for developing schizophrenia and related psychotic disorders; and 5) healthy comparison subjects from the same community as the patient and relative subjects. To address these goals, the Clinical Services Core will recruit and characterize the study subjects using a comprehensive diagnostic and psychopathological assessment battery, including laboratory and neuroradiological evaluations. The patients will be followed for six months to establish diagnostic stability. All data will be stored in a database managed by the Statistical and Data Management Core-D and will be accessible to Center investigators. The Core will also staff and conduct case conferences for the Brain Bank Core-B to achieve consensus diagnoses for all cases from whom post-mortem brain specimens are obtained. Data from the Clinical Services Core will be used to test the specific hypotheses regarding the etiopathophysiology of schizophrenia in Project 7-Carter and related projects funded through other mechanisms.