Perceived Cognitive function Item Bank for Children Who Undergo Cancer Treatment

接受癌症治疗的儿童的感知认知功能项目库

• 批准号: 7502068
• 负责人: JIN-SHEI LAI
• 金额: $ 45.2万
• 依托单位: NORTHSHORE UNIVERSITY HEALTHSYSTEM
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-30 至 2009-04-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7502068
• 关键词: 15 year old; Accounting; Acute; Address; Adolescent; Adult; Adverse effects; Aftercare; Age; Age-Years; Brain Neoplasms; Cancer Patient; Cancer Survivorship; Cause of Death; Child; Childhood; Children' s Oncology Group; Clinical; Condition; Development; Discrimination; Disease; Early identification; Ensure; Family; Foundations; Funding; Generic Drugs; Goals; Graph; Guidelines; Health Status; Individual; Information Systems; Institutes; Intervention; Late Effects; Lead; Length; Libraries; Life Style; Literature; Longevity; Lymphoblastic Leukemia; Lymphocyte; Malignant Childhood Neoplasm; Malignant Neoplasms; Measurement; Measures; Medical Technology; Metric; Modeling; Monitor; Neurocognitive; Neurocognitive Deficit; Neuropsychological Tests; Numbers; Parents; Patient Monitoring; Patient Outcomes Assessments; Patient Self-Report; Patients; Population; Property; Proxy; Psychometrics; Rate; Receiver Operating Characteristics; Reporting; Research; Research Personnel; Score; Screening procedure; Staging; Survivors; System; Testing; Time; United States; United States National Institutes of Health; Validity and Reliability; age group; base; cancer therapy; childhood cancer survivor; cognitive function; computerized; experience; follow-up; neuropsychological; programs; psychosocial; response; sound; theories; tool; treatment effect; user-friendly

DESCRIPTION (provided by applicant): Lifelong decrements in neurocognitive function (NF) are among the most prominent concerns for childhood cancer survivors, which can result in psychosocial problems of survivors and extend to the entire family. Routine assessment is especially critical for survivors as NF deficits may first appear years after the treatment. Current NF assessment relies on neuropsychological test battery, which is lengthy, expensive, and produces practice effects if it is administered routinely. Given these obstacles, there is a need for a measurement system that can provide brief and precise assessments tailored to the individual, thereby making it possible to screen patients who need comprehensive neuropsychological testing in busy clinical settings. To address this need, we propose to develop a comprehensive perceived cognitive function item bank (PCF) for children 7-21 years of age, which facilitates the development of individualized computerized adaptive testing (CAT) and short-forms that can serve as the screening tool. This bank would augment an existing adult PCF bank thereby providing the basis for psychometrically sound assessment across the disease continuum and life span. We propose the development of a parent proxy version for children of all ages and a self-reported version for children ages 1.3-21. The development of the pedsPCF bank will be accomplished through the successful completion of the following three aims. Aim 1 is to generate a perceived cognitive function item pool for the pediatric population. We will develop this pool by reviewing items from the existing adultPCF bank, an item library that we have built within the scope of two federally funded projects, and current literature. Items will be rigorously reviewed by clinicians, children and parents for their content validity. New items will be added to reflect developmental differences as necessary to ensure the comprehensiveness of the pool. Aim 2 is to examine the psychometric properties of the pedsPCF item bank(s) via the completion of two sub-aims: a) evaluate the essential unidimensionality of the pedsPCF bank; and b) calibrate the item bank(s) using item response theory (IRT) models. Aim 3 is to examine the clinical usefulness of the pedsPCF item bank(s) in relation to external clinical criteria. This includes: a) using discriminant function analysis and receiver operating characteristic curve approaches to establish cut scores; b) using IRT to develop user-friendly short-forms in screening patients for comprehensive testing; and c) using both anchored and distribution based approaches to identify minimally important differences in PCF. With the completion of this project, we hope to reach our ultimate goal of developing a measurement system that 1) can monitor patient perceived cognitive function throughout developmental stages, 2) can serve as the foundation for CAT and short-forms, which can then serve as a clinically meaningful screening tool.

描述（由申请人提供）：神经认知功能（NF）的终身衰退是儿童癌症幸存者最关注的问题之一，它可能导致幸存者的心理社会问题并延伸到整个家庭。常规评估对幸存者尤其重要，因为NF缺陷可能在治疗多年后首次出现。目前的NF评估依赖于神经心理学测试，这是冗长的，昂贵的，并且如果常规使用会产生练习效果。考虑到这些障碍，我们需要一种测量系统，能够提供针对个体的简短而精确的评估，从而使在繁忙的临床环境中筛选需要全面神经心理学测试的患者成为可能。为了满足这一需求，我们建议为7-21岁的儿童开发一个全面的感知认知功能题库（PCF），以促进个性化计算机适应测试（CAT）和简短表格的发展，作为筛查工具。该库将补充现有的成人PCF库，从而为整个疾病连续体和生命周期的心理测量学可靠评估提供基础。我们建议为所有年龄段的儿童开发一个家长代理版本，为1.3-21岁的儿童开发一个自我报告版本。pespcf银行的发展将通过成功完成以下三个目标来实现。目的1是为儿科人群建立一个感知认知功能项目库。我们将通过审查现有成人pcf库（我们在两个联邦资助项目的范围内建立的项目库）和当前文献中的项目来开发这个库。项目将由临床医生，儿童和家长严格审查其内容有效性。为了确保游泳池的全面性，将在必要时增加反映发展差异的新项目。目标2是通过完成两个子目标来检验pedsPCF题库的心理测量特性：a)评估pedsPCF题库的基本单维性；b)使用项目反应理论（IRT）模型校准题库。目的3是检查pedsPCF题库与外部临床标准的临床用途。这包括：a)使用判别函数分析和接收者工作特征曲线方法来建立切割分数；b)利用IRT编制便于使用的简短表格，以筛选病人进行全面测试；c)同时使用锚定方法和基于分布的方法来确定PCF的最小重要差异。随着这个项目的完成，我们希望能够达到我们的最终目标，即开发一种测量系统，1)可以监测患者在整个发育阶段的感知认知功能，2)可以作为CAT和short-forms的基础，然后可以作为临床有意义的筛查工具。