Identification and characterisation of novel RNAs involved in cardiovascular cell (de)differentiation.

参与心血管细胞分化（去）分化的新型 RNA 的鉴定和表征。

• 批准号: nhmrc : 1051485
• 负责人: A/Pr Jody Haigh
• 金额: $ 42.19万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identification-characterisation-novel-cell-dedifferentiation/112220
• 关键词: Identification; characterisation; novel; RNAs; involved

Several recent breakthroughs have made us realise that there is a lot of plasticity in cellular development, and we can now harness this plasticity to create stem cells that may eventually be used to repair the damaged heart and blood vessels after heart attacks and stroke. Here we will use mouse stem cells to discover the genetic factors responsible for a cell’s plasticity and memory in order to create pure populations of heart and blood vessel cells that can be used in repair settings.

最近的几项突破使我们意识到细胞发育具有很大的可塑性，我们现在可以利用这种可塑性来制造干细胞，这些干细胞最终可能用于修复心脏病发作和中风后受损的心脏和血管。在这里，我们将使用小鼠干细胞来发现负责细胞可塑性和记忆的遗传因素，以便创建可用于修复设置的纯心脏和血管细胞群。