Identification and characterisation of a novel genetic signature at the 5p15 region associated with risk of prostate cancer

与前列腺癌风险相关的 5p15 区域新遗传特征的鉴定和表征

• 批准号: nhmrc : 1050742
• 负责人: Dr Jyotsna Batra
• 金额: $ 40.74万
• 依托单位: Queensland University of Technology
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identification-characterisation-novel-prostate-cancer/112174
• 关键词: Identification; characterisation; novel; genetic; signature

We have recently replicated the genetic association of a region (5p15) with the risk of prostate cancer in Australian men. We now seek to identify the precise genetic variant behind this association, and the functional role of these novel gene/s and variants in disease pathology. Our results will provide a foundation for the development of sensitive and readily applicable lab-based screening tools to be used clinically and will also provide impetus for drug-targeted research by furthering our understanding on this multifactorial disease.

我们最近复制了一个区域（5p15）与澳大利亚男性前列腺癌风险的遗传关联。我们现在试图确定这种关联背后的精确遗传变异，以及这些新基因和变异在疾病病理学中的功能作用。我们的研究结果将为开发敏感且易于应用的临床实验室筛选工具提供基础，并通过进一步了解这种多因素疾病，为药物靶向研究提供动力。