The Unique Bioinorganic Chemistry of the Formation of Hydroxyaluminosilicates: A Case to Support a New Graphite Furnace Atomic Absorption Spectrometer

羟基铝硅酸盐形成的独特生物无机化学:支持新型石墨炉原子吸收光谱仪的案例

基本信息

  • 批准号:
    EP/G00983X/1
  • 负责人:
  • 金额:
    $ 7.06万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Research Grant
  • 财政年份:
    2008
  • 资助国家:
    英国
  • 起止时间:
    2008 至 无数据
  • 项目状态:
    已结题

项目摘要

Research in the Bioinorganic Chemistry Laboratory at Keele University is focussed upon the biological reactivity, availability and essentiality of the second and third most common elements of the Earth's crust, silicon and aluminium. In particular we have shown that aluminium binds silicon in forming hydroxyaluminosilicates and in doing so protects against the known toxicity of aluminium. It is essential to the continuing success of all of the research that we can measure low concentrations of aluminium accurately and reproducibly and we achieve this using instrumentation called a Graphite Furnace Atomic Absorption Spectrometer (GFAAS). Unfortunately our present machine which was bought in 1992 is no longer serviceable and we urgently require to replace it so that all of our research can continue without delay. In this application we have highlighted the ongoing research in our laboratory which uses GFAAS as well as prospective research and our committments to teaching undergraduate and postgraduate students with the view to demonstrating our need for a new GFAAS. Funds to support the buying of a new GFAAS are the subject of this application.
基尔大学生物无机化学实验室的研究重点是地壳中第二和第三常见元素硅和铝的生物反应性、可用性和必要性。特别是,我们已经表明,铝结合硅形成羟基硅酸铝,这样做可以防止已知的铝的毒性。对于所有研究的持续成功至关重要的是,我们可以准确和可重复地测量低浓度的铝,我们使用称为石墨炉原子吸收光谱仪(GFAAS)的仪器来实现这一目标。不幸的是,我们目前的机器是1992年购买的,已不能再使用,我们迫切需要更换它,以便我们所有的研究可以毫不拖延地继续下去。在这份申请中,我们强调了我们实验室正在进行的使用GFAAS的研究,以及未来的研究,以及我们对本科生和研究生教学的承诺,以证明我们需要一个新的GFAAS。支持购买新的GFAAS的资金是本申请的主题。

项目成果

期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
New insight into silica deposition in horsetail (Equisetum arvense).
  • DOI:
    10.1186/1471-2229-11-112
  • 发表时间:
    2011-07-29
  • 期刊:
  • 影响因子:
    5.3
  • 作者:
    Law C;Exley C
  • 通讯作者:
    Exley C
There is (still) too much aluminium in infant formulas.
  • DOI:
    10.1186/1471-2431-10-63
  • 发表时间:
    2010-08-31
  • 期刊:
  • 影响因子:
    2.4
  • 作者:
    Burrell SA;Exley C
  • 通讯作者:
    Exley C
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Christopher Exley其他文献

Monitoring the early aggregatory behaviour and size of Aβ<sub>1-42</sub> in the absence & presence of metal ions using dynamic light scattering
  • DOI:
    10.1016/j.jtemb.2021.126766
  • 发表时间:
    2021-09-01
  • 期刊:
  • 影响因子:
  • 作者:
    Emma Shardlow;Bakhtbilland Khan;Christopher Exley
  • 通讯作者:
    Christopher Exley
Aluminium in the human brain
  • DOI:
    10.1007/s00706-010-0417-y
  • 发表时间:
    2010-11-30
  • 期刊:
  • 影响因子:
    1.900
  • 作者:
    Christopher Exley;Emily R. House
  • 通讯作者:
    Emily R. House
Peer review versus editorial review and their role in innovative science
  • DOI:
    10.1007/s11017-012-9233-1
  • 发表时间:
    2012-10-02
  • 期刊:
  • 影响因子:
    1.500
  • 作者:
    Georg Steinhauser;Wolfram Adlassnig;Jesaka Ahau Risch;Serena Anderlini;Petros Arguriou;Aaron Zolen Armendariz;William Bains;Clark Baker;Martin Barnes;Jonathan Barnett;Michael Baumgartner;Thomas Baumgartner;Charles A. Bendall;Yvonne S. Bender;Max Bichler;Teresa Biermann;Ronaldo Bini;Eduardo Blanco;John Bleau;Anthony Brink;Darin Brown;Christopher Burghuber;Roy Calne;Brian Carter;Cesar Castaño;Peter Celec;Maria Eugenia Celis;Nicky Clarke;David Cockrell;David Collins;Brian Coogan;Jennifer Craig;Cal Crilly;David Crowe;Antonei B. Csoka;Chaza Darwich;Topiciprin del Kebos;Michele DeRinaldi;Bongani Dlamini;Tomasz Drewa;Michael Dwyer;Fabienne Eder;Raúl Ehrichs de Palma;Dean Esmay;Catherine Evans Rött;Christopher Exley;Robin Falkov;Celia Ingrid Farber;William Fearn;Sophie Felsmann;Jarl Flensmark;Andrew K. Fletcher;Michaela Foster;Kostas N. Fountoulakis;Jim Fouratt;Jesus Garcia Blanca;Manuel Garrido Sotelo;Florian Gittler;Georg Gittler;Juan Gomez;Juan F. Gomez;Maria Grazia Gonzales Polar;Jossina Gonzalez;Christoph Gösselsberger;Lynn Habermacher;Michael Hajek;Faith Hakala;Mary-Sue Haliburton;John Robert Hankins;Jason Hart;Sepp Hasslberger;Donalyn Hennessey;Andrea Herrmann;Mike Hersee;Connie Howard;Suzanne Humphries;Laeeth Isharc;Petar Ivanovski;Stephen Jenuth;Jens Jerndal;Christine Johnson;Yonas Keleta;Anna Kenny;Billie Kidd;Fritz Kohle;Jafar Kolahi;Marianne Koller-Peroutka;Lyubov Kostova;Arunachalam Kumar;Alejandro Kurosawa;Tony Lance;Michael Lechermann;Bernhard Lendl;Michael Leuchters;Evan Lewis;Edward Lieb;Gloria Lloyd;Angelika Losek;Yao Lu;Saadia Maestracci;Dennis Mangan;Alberto W. Mares;Juan Mazar Barnett;Valerie McClain;John Sydney McNair;Terry Michael;Lloyd Miller;Partizia Monzani;Belen Moran;Mike Morris;Georg Mößmer;Johny Mountain;Onnie Mary Moyo Phuthe;Marcos Muñoz;Sheri Nakken;Anne Nduta Wambui;Bettina Neunteufl;Dimitrije Nikolić;Devesh V. Oberoi;Gregory Obmode;Laura Ogar;Jo Ohara;Naion Olej Rybine;Bryan Owen;Kim Wilson Owen;Rakesh Parikh;Nicholas J. G. Pearce;Bernhard Pemmer;Chris Piper;Ian Prince;Terence Reid;Heiner Rindermann;Stefan Risch;Josh Robbins;Seth Roberts;Ajeandro Romero;Michael Thaddäus Rothe;Sergio Ruiz;Juliane Sacher;Wolfgang Sackl;Markus Salletmaier;Jairaj Sanand;Clemens Sauerzopf;Thomas Schwarzgruber;David Scott;Laura Seegers;David Seppi;Kyle Shields;Jolanta Siller-Matula;Beldeu Singh;Sibusio Sithole;Florian Six;John R. Skoyles;Jildou Slofstra;Daphne Anne Sole;Werner F. Sommer;Mels Sonko;Chrislie J. Starr-Casanova;Marjorie Elizabeth Steakley;Wolfgang Steinhauser;Konstantin Steinhoff;Johannes H. Sterba;Martin Steppan;Reinhard Stindl;Joe Stokely;Karri Stokely;Gilles St-Pierre;James Stratford;Christina Streli;Carl Stryg;Mike Sullivan;Johann Summhammer;Amhayes Tadesse;David Tavares;Laura Thompson;Alison Tomlinson;Jack Tozer;Siro I. Trevisanato;Michaela Trimmel;Nicole Turner;Paul Vahur;Jennie van der Byl;Tine van der Maas;Leo Varela;Carlos A. Vega;Shiloh Vermaak;Alex Villasenor;Matt Vogel;Georg von Wintzigerode;Christoph Wagner;Manuel Weinberger;Peter Weinberger;Nick Wilson;Jennifer Finocchio Wolfe;Michael A. Woodley;Ian Young;Glenn Zuraw;Nicole Zwiren
  • 通讯作者:
    Nicole Zwiren
The influence of aluminium and copper upon the early aggregatory behaviour and size of Islet amyloid polypeptide under simulated physiological conditions
  • DOI:
    10.1016/j.jtemb.2022.127027
  • 发表时间:
    2022-09-01
  • 期刊:
  • 影响因子:
  • 作者:
    Emma Shardlow;Lewis Brown;Christopher Exley
  • 通讯作者:
    Christopher Exley
The localisation of aluminium in the tissues of the rainbow trout
  • DOI:
    10.1016/0044-8486(92)90391-w
  • 发表时间:
    1992-01-01
  • 期刊:
  • 影响因子:
  • 作者:
    Christopher Exley;William Struthets
  • 通讯作者:
    William Struthets

Christopher Exley的其他文献

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{{ truncateString('Christopher Exley', 18)}}的其他基金

Mechanism of toxicity of aluminium-based adjuvant (ABA) nanomaterials
铝基佐剂(ABA)纳米材料的毒性机制
  • 批准号:
    MR/J006939/1
  • 财政年份:
    2012
  • 资助金额:
    $ 7.06万
  • 项目类别:
    Research Grant
A Combined Computational and Benchtop Chemistry Approach to a Model of the Formation, Growth and Precipitation of Hydroxyaluminosilicates.
羟基铝硅酸盐形成、生长和沉淀模型的计算和台式化学相结合的方法。
  • 批准号:
    EP/J004146/1
  • 财政年份:
    2011
  • 资助金额:
    $ 7.06万
  • 项目类别:
    Research Grant

相似海外基金

Conference: Metals in Biology Gordon Research Conference and Bioinorganic Chemistry Gordon Research Seminar
会议:金属在生物学戈登研究会议和生物无机化学戈登研究研讨会
  • 批准号:
    2327975
  • 财政年份:
    2023
  • 资助金额:
    $ 7.06万
  • 项目类别:
    Standard Grant
Molecular Electrochemistry as Enabling Technology in Inorganic and Bioinorganic Chemistry
分子电化学作为无机和生物无机化学的使能技术
  • 批准号:
    RGPIN-2020-05851
  • 财政年份:
    2022
  • 资助金额:
    $ 7.06万
  • 项目类别:
    Discovery Grants Program - Individual
Bioinorganic Chemistry
生物无机化学
  • 批准号:
    CRC-2016-00245
  • 财政年份:
    2022
  • 资助金额:
    $ 7.06万
  • 项目类别:
    Canada Research Chairs
Probing bioinorganic chemistry processes in the bloodstream
探索血液中的生物无机化学过程
  • 批准号:
    RGPIN-2019-04376
  • 财政年份:
    2022
  • 资助金额:
    $ 7.06万
  • 项目类别:
    Discovery Grants Program - Individual
New Chemistry from Biology with Bioinorganic Chemistry
生物学与生物无机化学的新化学
  • 批准号:
    RGPIN-2019-05470
  • 财政年份:
    2022
  • 资助金额:
    $ 7.06万
  • 项目类别:
    Discovery Grants Program - Individual
Bioinorganic chemistry of metalloproteins and tetrapyrroles
金属蛋白和四吡咯的生物无机化学
  • 批准号:
    RGPIN-2020-06545
  • 财政年份:
    2022
  • 资助金额:
    $ 7.06万
  • 项目类别:
    Discovery Grants Program - Individual
Metal Virulence and Therapeutic Factors in Pathogen Bioinorganic Chemistry
病原体生物无机化学中的金属毒力和治疗因素
  • 批准号:
    DP210101632
  • 财政年份:
    2021
  • 资助金额:
    $ 7.06万
  • 项目类别:
    Discovery Projects
Probing bioinorganic chemistry processes in the bloodstream
探索血液中的生物无机化学过程
  • 批准号:
    RGPIN-2019-04376
  • 财政年份:
    2021
  • 资助金额:
    $ 7.06万
  • 项目类别:
    Discovery Grants Program - Individual
Bioinorganic chemistry of metalloproteins and tetrapyrroles
金属蛋白和四吡咯的生物无机化学
  • 批准号:
    RGPIN-2020-06545
  • 财政年份:
    2021
  • 资助金额:
    $ 7.06万
  • 项目类别:
    Discovery Grants Program - Individual
Bioinorganic Chemistry
生物无机化学
  • 批准号:
    CRC-2016-00245
  • 财政年份:
    2021
  • 资助金额:
    $ 7.06万
  • 项目类别:
    Canada Research Chairs
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