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Communication of Genetic and Environmental Risks in Colorectal Cancer Prevention

结直肠癌预防中遗传和环境风险的交流

基本信息

批准号：
7532876
负责人：
Catharine Wang
金额：
$ 13.36万
依托单位：
FOX CHASE CANCER CENTER
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-01 至 2009-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7532876
关键词：
Adherence Adoption Age Area Award Awareness Behavior Behavioral Belief Cancer Etiology Cancer Survivor Categories Chronic Disease Class Cognitive Colonoscopy Colorectal Colorectal Cancer Communication Complex Computer information processing Condition Data Development Diagnosis Diet Disease Eating Effectiveness Environment Environmental Risk Factor Evaluation Event Family Cancer History Family health status Family history of Feedback Female Foundations Future Gender General Population Genes Genetic Genetic Determinism Genetic Risk Goals Health Health Benefit Health Communication Health behavior Heredity Human Individual Informal Social Control Inherited Intake Intervention Knowledge Life Style Light Malignant Neoplasms Mediating Medical Medical Surveillance Mentors Methodology Methods Modeling Modification Motivation Nature Outcome Pattern Perception Play Predisposing Factor Prevention Preventive Principal Investigator Process Protocols documentation Psychological adjustment Psychometrics Public Domains Public Health Recommendation Recording of previous events Research Research Personnel Research Training Risk Risk Factors Role Science Screening for cancer Screening procedure Severities Sigmoidoscopy Statistical Methods Support of Research Surgeon Surveys Testing Thinking Time Training Training Programs Translating Treatment Protocols Work base behavior change behavior influence cancer diagnosis cancer genetics cancer risk cancer site career colorectal cancer prevention colorectal cancer screening coping design disorder risk fruits and vegetables genetic technology genome sequencing insight male new technology programs psychosocial research study response statistics theories therapy design

项目摘要

DESCRIPTION (provided by applicant): The overall goal of this career award proposal is to enable Dr. Wang to become an independent investigator n the design of interventions to communicate messages about genetic and environmental risk, with a focus on colorectal cancer. The effective communication of genetic and environmental risk factor information has grown increasingly important as advances in genetic technology continue to shed new light on their contributions to colorectal cancer risk. To date, little is known about how best to communicate risk factor information to increase behavioral motivation, thus limiting the application of these new technologies for public health benefit. The impact of communication about cancer risk factors depends, in part, on the prior beliefs and cognitive representations held about the disease feedback being conveyed. In particular, causal attributions - the beliefs people have about the causes of colorectal cancer - are an important, but understudied, determinant of whether and to what extent individuals take behavioral action to reduce the likelihood of developing the disease. A better understanding of causal attributions for colorectal cancer among the general population is essential in order to systematically and comprehensively delineate how people think about the causes of cancer, and identify those attributions that facilitate, or undermine, screening adherence and lifestyle change. Using a combination of survey and experimental research methodologies, two studies are being proposed that build on each other in logical sequence to 1) describe the nature of causal attributions for colorectal cancer and their association with screening and lifestyle behaviors, and 2) begin to experimentally test the impact of genetic and environmentally-focused risk communication messages on patterns of causal attributions and health behaviors among unaffected individuals. The training plan proposed supports this research by providing the necessary advanced mentoring and coursework in communication science, psychometric methods, intervention strategies, and advanced statistics. This will enable the PI to effectively conduct the studies and prepare her for an R01 submission in year 5, building on the findings obtained to create more refined messages for colorectal screening and prevention. This synergistic program of training and research will be essential to understanding how individuals respond to risk communication messages for colorectal cancer, as well as other cancer sites. Perhaps most importantly, the knowledge gained from these studies will be critical to inform the development and evaluation of theory-guided tailored interventions that focus on conveying genetic and/or environmental risk information to the general population in efforts to promote behavior change and, ultimately, public health benefits.

描述（由申请人提供）：该职业奖提案的总体目标是使王博士成为一名独立研究者，设计干预措施以传达有关遗传和环境风险的信息，重点关注结直肠癌。随着基因技术的进步不断揭示其对结直肠癌风险的贡献，遗传和环境风险因素信息的有效沟通变得越来越重要。迄今为止，人们对如何最好地传达风险因素信息以增加行为动机知之甚少，从而限制了这些新技术在公共健康方面的应用。关于癌症风险因素的沟通的影响部分取决于先前对所传达的疾病反馈的信念和认知表征。特别是，因果归因——人们对结直肠癌病因的信念——是一个重要但尚未充分研究的决定因素，决定着个人是否以及在多大程度上采取行为行动来降低患这种疾病的可能性。更好地了解普通人群中结直肠癌的因果归因至关重要，以便系统、全面地描述人们如何看待癌症的原因，并确定那些促进或破坏筛查依从性和生活方式改变的归因。结合调查和实验研究方法，正在提出两项研究，这些研究按逻辑顺序相互构建，以 1) 描述结直肠癌因果归因的性质及其与筛查和生活方式行为的关联，2) 开始通过实验测试遗传和环境风险沟通信息对未受影响个体的因果归因和健康行为模式的影响。提出的培训计划通过提供必要的传播科学、心理测量方法、干预策略和高级统计方面的高级指导和课程来支持这项研究。这将使 PI 能够有效地进行研究，并为第 5 年提交 R01 做好准备，并根据所获得的结果为结直肠筛查和预防创建更完善的信息。这种培训和研究的协同计划对于了解个人如何应对结直肠癌以及其他癌症部位的风险沟通信息至关重要。也许最重要的是，从这些研究中获得的知识对于制定和评估以理论为指导的定制干预措施至关重要，这些干预措施的重点是向普通人群传达遗传和/或环境风险信息，努力促进行为改变，并最终促进公共卫生效益。