Time Resolved MRA of the Intracranial Vasculature

这项工作的广泛、长期的目标是改善患者的诊断和治疗 神经血管疾病。本病的诊断和治疗计划往往需要使用导管。 基于X-射线血管造影(XRA)。导管血管造影术是目前的参考标准。 但患者和医生都暴露在高剂量的辐射下， 需要动脉穿刺术，注射肾毒性造影剂，并有轻微的风险 卒中。使用动脉内导管治疗XRA需要住院康复，增加了 病人护理费用。基于磁共振成像(MRI)的血管造影图像被广泛应用 并且减少了XRA在许多血管疾病诊断中的使用 床。然而，由于需要高帧图像(高达6帧/秒)来捕获团注 动力学方面，XRA仍是常规的颅内血管成像方法。我们正在开发 一种基于径向采样滑动窗口的基于MRI的颅内XRA替代方法 重建。磁共振血管成像的微创性质将降低患者的风险。 对大脑进行诊断性成像。使用我们的方法进行磁共振血管成像可以达到 捕捉推注动态所需的帧和空间分辨率 用更具侵袭性的XRA观察。在拟议的工作中，我们将实现我们的脉冲序列， 在体模、健康正常人身上验证脉搏序列，并与XRA直接比较 在病人身上。我们将检验以下假设： 具体目标1：我们假设滑动窗口径向MRA可以更好地描述流动 与传统的块状MRI采集相比，动态性能更好。 具体目标2：我们假设约束径向滑动窗口图像重建 采集将在不改变脑血管成像的情况下改善颅内血管的显示 流动动力学。 具体目标3：我们假设滑动窗径向MRA可以准确地显示 患者的血管系统异常。 在这个项目成功完成后，我们将开发和验证一个非侵入性附件 对于颅内X射线血管成像，我们建议开发一种基于MRI的成像方案，用于无创的颅内成像 脉管系统。我们的目标是开发一种有助于诊断和治疗的脉冲序列 规划一系列神经血管疾病。目前解决这个问题的方法是导管- 基于x射线血管造影术，这是侵入性的，具有一定的中风风险，并以这两个患者为研究对象 以及医生对电离辐射的反应。这个项目的成功完成将导致 正在进行侵入性成像程序，从而降低了患者的风险。

The broad, long-term goal of this work is to improve the diagnosis and treatment of patients with neurovascular disease. The diagnosis and treatment planning of often require the used of catheter- based x-ray angiography (XRA). Catheter angiography is the current referenced standard for intracranial angiography but exposes both the patients and physicians to high doses of radiation, requires an arterial puncture, the injection of nephrotoxic contrast agents and carries a slight risk of stroke. The use of intra-arterial catheters for XRA requires a hospital stay for recovery, adding to the cost of patient care. Magnetic Resonance Imaging (MRI) based angiographic images are widely available, and have reduced the use of XRA for the diagnosis of vascular disease in many vascular beds. However, due to the need of high frame images (up to 6 frames/sec) to capture bolus dynamics, XRA is still routinely performed to image the intracranial vasculature. We are developing an MRI-bases alternative to intracranial XRA based on using radial sampling and sliding window reconstruction. The minimally invasive nature of MR angiography will reduce the risk to patients undergoing diagnostic imaging of the brain. Using our approach to MR angiography can reach the frames and spatial resolution needed to capture the bolus dynamics that are normally observed with more invasive XRA. In the proposed work, we will implement our pulse sequence, validate the pulse sequence in phantoms, healthy normal subject, and in direct comparison with XRA in patients. We will test the following hypotheses: Specific Aim 1: We hypothesize that sliding window radial MRA can better depict flow dynamics than traditional block-wise MRI acquisitions. Specific Aim 2: We hypothesize that constrain reconstruction of radial sliding window images acquisition will improve the depiction of intracranial blood vessels without altering the imaging of flow dynamics. Specific Aim 3: We hypothesize that sliding window radial MRA can accurately depict the vasculature abnormalities in patients. Upon successful completion of this project we will have developed and validated a non-invasive adjunct to intracranial X-ray angiography We propose to develop an MRI-based imaging protocol for no-invasive imaging of the intracranial vasculature. Our goal is to develop a pulse sequence that can aid in the diagnosis and treatment planning of a wide range of neurovascular diseases. The current approach to this problem is catheter- based x-ray angiography which is invasive, carries a definite risk of stroke and subjects both patients and physicians to ionizing radiation. The successful completion of this project will results in fewer invasive imaging procedures being performed, resulting reduced risk to patients.