Development of Novel MR Imaging for Ischemic Stroke Evaluation

摘要 这项研究的广泛和长期目标是改善缺血性中风的诊断和治疗。在这 提出工作建议，开发基于核磁共振的生物医学成像新技术。根据最近的核磁共振成像 基于成功使用MRI进行中风分流的成像试验，有一个未得到满足的需求来改善急性 卒中患者的时相生理和血管造影表现。在本提案中，我们将制定、验证和执行 首次能够对体积变化进行成像的新MRI脉冲序列的初步研究 在脑灌注、桶侧支血流、组织氧合在10分钟以内。我们的研究小组 汇聚两家顶级研究机构，使用 新的缺血性卒中动物模型。此模型的使用将允许直接显示软脑膜附属物 血流、脑生理局部改变和血流增强治疗的假想反应。

Abstract The broad, long term goal of this research is to improve the diagnosis and treatment of ischemic stroke. In this proposed work we will develop new biomedical imaging technologies based on MRI. In light of recent MRI based imaging trials which successfully use MRI for stroke triage, there is an unmet need to improve acute phase physiologic and angiographic imaging in stroke. In this proposal we will develop, validate and perform a pilot study of new MRI pulse sequences that are capable, for the first time, the imaging of volumetric changes in cerebral perfusion, pail collateral flow, and tissue oxygenation in under 10 minutes. Our research group brings together two top-tier research institutes to interactively alter and image cerebral physiology using a novel animal model of ischemic stroke. The use of this model will allow direct visualization of the pial collateral flow, local alteration in cerebral physiology and the hypothesized response to flow augmentation therapy.