Mechanisms of Action of Silymarin for Hepatitis C

水飞蓟素治疗丙型肝炎的作用机制

• 批准号: 7384347
• 负责人: STEPHEN J. POLYAK
• 金额: $ 24.77万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7384347
• 关键词: Adverse effects; Affect; Anti-Inflammatory Agents; Anti-inflammatory; Antioxidants; Antiviral Agents; Arts; Botanicals; Caring; Cells; Chronic; Chronic Hepatitis C; Clinical Treatment; Clinical Trials; Complementary and alternative medicine; Data; Disease; Dose; Fostering; Foundations; Fractionation; Future; Genetic Transcription; Genotype; Grant; Gray unit of radiation dose; Health; Hepatitis C; Hepatitis C virus; Hepatocyte; Human; Industry; Infectious hepatitides; Inflammatory; Inflammatory Response; Interferons; Lead; Liver; Liver diseases; Milk Thistle; Molecular; Oxidation-Reduction; Oxidative Stress; Pathway interactions; Patients; Plant Preparations; Plants; Preparation; Proteins; Reporting; Research; Research Design; Reverse Transcriptase Polymerase Chain Reaction; Ribavirin; Signal Pathway; Signal Transduction; Signal Transduction Pathway; Silymarin; Solid; Source; Standardization; Standards of Weights and Measures; System; Therapeutic; Thinking; Time; Treatment Protocols; Viral; Virus; Western Blotting; anti-hepatitis C; base; chemokine; cytokine; improved; interferon therapy; novel; pre-clinical research; programs; prophylactic; response; success; transcription factor; viral RNA; virus culture

DESCRIPTION (provided by applicant): Hepatitis C virus (HCV) is a global disease of the liver that affects over 170 million people. The only approved treatment for chronic hepatitis C is interferon (IFN) and ribavirin, which only cures about 50% of infected patients. Given the chance of success and significant side effects associated with IFN therapy, many patients consume botanicals such as milk thistle. The active ingredient in milk thistle is Silymarin (SM), which is thought to promote a healthy liver. However, exactly how SM promotes a healthy liver is not known. Furthermore, the botanical industry lacks proper standardization of the source plants and preparation of botanical extracts. We propose to determine how SM promotes a healthy liver, using a carefully standardized and validated preparation of SM. We hypothesize that SM acts as an anti-inflammatory and anti-viral agent to protect the liver from HCV infection. We believe these studies will provide a solid foundation for future clinical trials of SM in patients with chronic hepatitis C. Project Narrative: Chronic hepatitis C is a global disease of the liver that affects over 170 million people. It is caused by a hepatitis C virus (HCV). Treatment options for infected people are limited, expensive, associated with major side effects, and frequently of limited efficacy. This project will investigate the mechanisms of hepatoprotection of the botanical silymarin to provide a rational basis for alternative and complementary medicine approaches to treatment of chronic hepatitis C.

描述（由申请人提供）：丙型肝炎病毒（HCV）是一种全球性肝脏疾病，影响超过1.7亿人。唯一批准的治疗慢性丙型肝炎的方法是干扰素（IFN）和利巴韦林，只能治愈约50%的感染患者。考虑到成功的机会和与IFN治疗相关的显著副作用，许多患者食用植物如奶蓟。水飞蓟中的活性成分是水飞蓟素（SM），被认为可以促进肝脏健康。然而，SM究竟如何促进健康的肝脏尚不清楚。此外，植物工业缺乏对来源植物和植物提取物制备的适当标准化。我们建议确定SM如何促进健康的肝脏，使用仔细标准化和验证的SM制剂。我们假设SM作为抗炎和抗病毒剂来保护肝脏免受HCV感染。我们相信这些研究将为SM在慢性丙型肝炎患者中的未来临床试验提供坚实的基础。项目叙述：慢性丙型肝炎是一种全球性肝脏疾病，影响超过1.7亿人。它是由丙型肝炎病毒（HCV）引起的。受感染者的治疗选择有限，昂贵，与主要副作用有关，并且通常疗效有限。本研究将探讨植物性水飞蓟素的保肝作用机制，为慢性丙型肝炎的替代和补充治疗提供理论依据。