Bioadhesive Membrane Construct for Hernia Repair

用于疝气修复的生物粘附膜结构

• 批准号: 7612815
• 负责人: Bruce P Lee
• 金额: $ 11.63万
• 依托单位: NERITES CORPORATION
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-30 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7612815
• 关键词: Abdomen; Adhesions; Adhesives; Amino Acids; Animal Model; Area; Binding; Biological; Biomechanics; Biomimetics; Bioprosthesis device; Breathing; Catechols; Cells; Chronic; Collagen; Deposition; Development; Dopa; Drug Formulations; Environment; Evaluation; Exhibits; Family suidae; Fibroblasts; Film; Foreign-Body Reaction; Future; Generations; Glues; Government; Hernia; Human; Immobilization; Implant; Infection; Laparoscopic Surgical Procedures; Lead; Location; Marines; Mechanics; Medical Device; Membrane; Metals; Methods; Muscle; Mussels; Nerve; Nerve Tissue; Operative Surgical Procedures; Organ; Outcome; Patients; Performance; Persons; Phase I Clinical Trials; Phase II Clinical Trials; Polymers; Postoperative Period; Preparation; Property; Prosthesis; Proteins; Psychological reinforcement; Public Health; Purpose; Quality of life; Range; Rate; Reaction; Reconstructive Surgical Procedures; Recurrence; Research; Resistance; Risk; Safety; Saline; Secure; Series; Side; Site; Source; Specific qualifier value; Sterilization for infection control; Surface; Surgical sutures; Techniques; Testing; Textiles; Tissue Engineering; Tissues; United States; Water; abdominal wall; adhesive polymer; base; biomaterial compatibility; implantation; improved; in vivo; interest; migration; new technology; novel; prevent; repaired; sample fixation; scaffold; size; success

DESCRIPTION (provided by applicant): A hernia occurs when part of an internal organ bulges through a weak area of muscle, with most hernias occurring in the abdomen. Surgical hernia repair is one of the most commonly performed surgeries in the US. While using prosthetic mesh as a reinforcement has significantly improved surgical outcomes, the rate of hernia recurrence remains high (30-50%). Current prosthetic materials are associated with numerous complications, including increased risk of infection, prosthetic shrinkage and host-foreign body reactions, leading to a diminished postoperative patient quality of life. The recent introduction of various biologic prosthetic meshes derived from modified human or porcine tissue have demonstrated lower rates of infection as compared to their synthetic counterparts. Equally important, effective immobilization of the mesh against the abdominal wall is critical to hernia repair success. Currently, sutures and staples are used to hold synthetic and biologic meshes in place, but these can be a source of nerve damage and chronic discomfort. Thus, there continues to be a need to develop alternative fixation methods that can effectively secure the mesh to the abdominal wall as well as improve long- term biocompatibility of these meshes. Marine mussels provided the inspiration for the new technology presented in this proposal. By releasing rapidly hardening, tightly binding adhesive proteins, marine mussels have the ability to anchor themselves to various surfaces in a wet, turbulent, and saline environment. Both natural proteins and their synthetic mimics can bind strongly to various substrates ranging from biological tissues to metal surfaces. In this proposal, biomimetic synthetic adhesives will be combined with a natural scaffold to create a novel bioadhesive prosthetic. The intent of such a construct is to create an effective repair with minimized long-term infection rate and chronic patient discomfort typically associated with permanent prosthetic materials. The feasibility of using such a material for hernia repair will be tested. PUBLIC HEALTH RELEVANCE Bioadhesive Membrane Construct for Hernia Repair Hernia repair is one of the most frequently performed surgical procedures in the United States. Current repair methods and materials have exhibited mixed success, but each has limitations such as high recurrence rate and persistent patient discomfort. The development and evaluation of a novel bioadhesive membrane construct for hernia repair is described here.

描述（由申请人提供）：当一部分内脏的肌肉区域凸起时，发生疝气，大多数疝发生在腹部。手术疝修复是美国最常见的手术之一。虽然使用假体网状用作增强剂可以显着改善手术结果，但疝气复发的速度仍然很高（30-50％）。当前的假体材料与许多并发症有关，包括增加感染的风险，假体收缩和宿主外体反应，从而导致术后患者生活质量降低。与合成对应物相比，最近引入了从改良的人类或猪组织中得出的各种生物假体网状网状物显示出较低的感染率。同样重要的，有效的固定固定在腹壁上对于疝气修复成功至关重要。目前，缝合线和钉书钉用于将合成和生物晶状固定在适当的位置，但这些可能是神经损伤和慢性不适的根源。因此，仍然需要开发替代的固定方法，这些方法可以有效地将网格固定在腹壁上，并提高这些网格的长期生物相容性。海洋贻贝为本提案中提出的新技术提供了灵感。通过释放快速硬化，紧密结合的粘合剂蛋白，海洋贻贝可以在潮湿，湍流和盐水环境中锚定在各种表面上。天然蛋白质及其合成模拟物都可以与从生物组织到金属表面的各种底物强烈结合。在此提案中，仿生合成粘合剂将与天然脚手架结合使用，以创建一种新型的生物粘附假体。这种结构的目的是通过最小化长期感染率和慢性患者不适，通常与永久性假体材料相关。将测试使用这种材料进行疝气修复的可行性。公共卫生相关性的生物粘附膜构造用于疝气修复疝修复是美国最常执行的手术程序之一。当前的维修方法和材料表现出混合成功，但每种方法都有限制，例如高复发率和持续的患者不适。这里描述了一种新型生物粘附膜构建体的开发和评估。