Microchip-Based Perchlorate Analyzer for Water Remediation Monitoring and Field A

用于水体修复监测和现场 A 的微芯片高氯酸盐分析仪

• 批准号: 7612102
• 负责人: Dale M Willard
• 金额: $ 12.08万
• 依托单位: ADVANCED MICROLABS, LLC
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-25 至 2010-09-24
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7612102
• 关键词: Address; Air Bags; Anions; Beds; Businesses; California; Chemistry; Colorado; Communities; Coupled; Cytarabine/Etoposide/Mitoxantrone; Detection; Development; Developmental Delay Disorders; Devices; Dyes; Engineering; Environment; Equipment; Event; Exposure to; Fertilizers; Flare; Funding; Generations; Government; Hour; Laboratories; Legal patent; Maintenance; Measurement; Measures; Medical; Membrane; Methods; Monitor; Numbers; Operative Surgical Procedures; Paint; Particulate Matter; Perchlorates; Phase; Plant Resins; Power Sources; Prevalence; Procedures; Process; Public Health; Pump; Resources; Running; Sampling; Series; Site; Small Business Technology Transfer Research; Solid; Source; Standards of Weights and Measures; Surface; System; Technology; Technology Transfer; Testing; Thyroid Function Tests; Time; Training; United States Environmental Protection Agency; Universities; Validation; Water; Work; base; cost; design; detector; drinking water; exposed human population; instrument; instrumentation; interest; micro-total analysis system; microchip; monitoring device; prototype; remediation; superfund site; voltage; water sampling; water sampling/testing

DESCRIPTION (provided by applicant): This Small Business Technology Transfer Phase I project will develop a prototype online perchlorate monitor for a resin bed perchlorate remediation reactor. The device will be have less than 4 ppb limit- of-detection, provide results in less than 3 min., and require only periodic microchip replacement as routine maintenance. Currently, perchlorate can only be detected below 10 ppb using laboratory based equipment requiring trained technicians and, most importantly, at least several hours of time, and therefore, impractical for online monitoring. The Henry Group at Colorado State University has recently demonstrated sub ppb perchlorate detection using a patent-pending lab-on-a-chip technology with results that include real water sample testing. This technology opens the door for online monitoring of perchlorate remediation operations, which will significantly reduce the costs. Entire resin beds costing $100k in materials and additional costs in disposal would no longer be needed. This Phase I proposal will: 1. Develop pumps, valves, instrumentation, etc. to assemble a field deployable device, 2. Optimize our microchip functions by incorporating a sample membrane barrier and assessing nonhazardous alternative internal standards, and 3. Method validation and field testing. PUBLIC HEALTH RELEVANCE: Human exposure to perchlorate is of concern because of the potential for impaired thyroid function, leading to a number of developmental delays and other medical problems. Its prevalence in the environment only gained interest in the late 1990's, once a method was developed for its detection at the 4 ppb level. In 2005 after being added to the Environmental Protection Agency's (EPA) Unregulated Contaminant Monitoring Rule (UCMR1) list, a sampling of 2800 large water systems and 800 smaller systems, representing less than 10% of all US water systems, revealed contamination in 153 sites over 25 states. As of 2005, 120 remediation projects were underway, including 15 superfund sites, costing hundred's of millions of dollars to fund, mostly coming from government coffers. Our online monitoring device will significantly reduce costs for remediation. In addition to lowering costs to existing remediation, it will also allow smaller communities address cleanup that would otherwise not have enough resources.

描述（由申请人提供）：这个小型企业技术转移阶段I项目将在线开发原型的高氯酸盐监视器，用于树脂床高氯酸盐修复反应堆。该设备的检测极限少于4 ppb，在不到3分钟的时间内提供结果，并且仅需要定期的微芯片替换作为常规维护。目前，只能使用需要训练有素的技术人员的基于实验室的设备来检测高氯酸盐，最重要的是，至少几个小时的时间，因此对于在线监视不切实际。科罗拉多州立大学的亨利集团（Henry Group）最近使用了申请专利的实验室芯片技术，其结果包括实际水样测试。这项技术为在线监视高氯酸盐补救操作打开了大门，这将大大降低成本。整个材料的成本为10万美元，不再需要支付的额外费用。该阶段I建议将：1。开发泵，阀门，仪器等。组装可部署的设备，2。通过合并样品膜屏障并评估非危害性替代性内部标准，以及3。方法验证和现场测试，通过合并样品膜屏障来优化我们的微芯片功能。公共卫生相关性：由于甲状腺功能受损而导致许多发育延迟和其他医疗问题，人类接触高氯酸盐的暴露引起了人们的关注。一旦开发出一种在4 ppb水平的检测方法，它在1990年代后期才引起了人们的兴趣。在2005年被添加到环境保护局（EPA）不受监管的污染物监测规则（UCMR1）列表中后，对2800个大型水系统和800个较小的系统进行了采样，占美国水系统的不到10％的少于10％，揭示了25个州以上153个地点的污染物。截至2005年，正在进行120个补救项目，其中包括15个超级基金网站，耗资数百万美元的资金，主要来自政府金库。我们的在线监视设备将大大降低补救成本。除了降低现有补救的成本外，它还允许较小的社区解决否则资源不足的清理工作。