Microchip-Based Perchlorate Analyzer for Water Remediation Monitoring and Field A

用于水体修复监测和现场 A 的微芯片高氯酸盐分析仪

• 批准号: 7845336
• 负责人: Dale M Willard
• 金额: $ 3.22万
• 依托单位: ADVANCED MICROLABS, LLC
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-25 至 2010-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7845336
• 关键词: Address; Air Bags; Anions; Beds; Businesses; California; Chemistry; Colorado; Communities; Coupled; Detection; Development; Developmental Delay Disorders; Devices; Dyes; Engineering; Environment; Equipment; Event; Exposure to; Fertilizers; Flare; Funding; Generations; Government; Hour; Laboratories; Legal patent; Maintenance; Measurement; Measures; Medical; Membrane; Methods; Monitor; Operative Surgical Procedures; Paint; Particulate Matter; Perchlorates; Phase; Plant Resins; Power Sources; Prevalence; Procedures; Process; Pump; Resources; Running; Sampling; Series; Site; Small Business Technology Transfer Research; Solid; Source; Surface; System; Technology; Technology Transfer; Testing; Thyroid Function Tests; Time; Training; United States Environmental Protection Agency; Universities; Validation; Water; Work; base; cost; design; detector; drinking water; exposed human population; instrument; instrumentation; interest; micro-total analysis system; microchip; monitoring device; prototype; public health relevance; remediation; superfund site; voltage; water sampling; water sampling/testing

DESCRIPTION (provided by applicant): This Small Business Technology Transfer Phase I project will develop a prototype online perchlorate monitor for a resin bed perchlorate remediation reactor. The device will be have less than 4 ppb limit- of-detection, provide results in less than 3 min., and require only periodic microchip replacement as routine maintenance. Currently, perchlorate can only be detected below 10 ppb using laboratory based equipment requiring trained technicians and, most importantly, at least several hours of time, and therefore, impractical for online monitoring. The Henry Group at Colorado State University has recently demonstrated sub ppb perchlorate detection using a patent-pending lab-on-a-chip technology with results that include real water sample testing. This technology opens the door for online monitoring of perchlorate remediation operations, which will significantly reduce the costs. Entire resin beds costing $100k in materials and additional costs in disposal would no longer be needed. This Phase I proposal will: 1. Develop pumps, valves, instrumentation, etc. to assemble a field deployable device, 2. Optimize our microchip functions by incorporating a sample membrane barrier and assessing nonhazardous alternative internal standards, and 3. Method validation and field testing. PUBLIC HEALTH RELEVANCE: Human exposure to perchlorate is of concern because of the potential for impaired thyroid function, leading to a number of developmental delays and other medical problems. Its prevalence in the environment only gained interest in the late 1990's, once a method was developed for its detection at the 4 ppb level. In 2005 after being added to the Environmental Protection Agency's (EPA) Unregulated Contaminant Monitoring Rule (UCMR1) list, a sampling of 2800 large water systems and 800 smaller systems, representing less than 10% of all US water systems, revealed contamination in 153 sites over 25 states. As of 2005, 120 remediation projects were underway, including 15 superfund sites, costing hundred's of millions of dollars to fund, mostly coming from government coffers. Our online monitoring device will significantly reduce costs for remediation. In addition to lowering costs to existing remediation, it will also allow smaller communities address cleanup that would otherwise not have enough resources.

描述（由申请人提供）：这个小企业技术转让第一阶段项目将开发一个原型在线高氯酸盐监测树脂床高氯酸盐修复反应器。该设备的检测限将低于4 ppb，在3分钟内提供结果，并且仅需要定期更换微芯片作为日常维护。目前，使用实验室设备只能检测到低于10 ppb的高氯酸盐，这需要训练有素的技术人员，最重要的是，至少需要几个小时的时间，因此，在线监测是不切实际的。科罗拉多州立大学的亨利小组最近展示了使用正在申请专利的芯片实验室技术进行亚ppb高氯酸盐检测，结果包括真实的水样测试。该技术为在线监测高氯酸盐修复操作打开了大门，这将大大降低成本。整个树脂床成本10万美元的材料和额外的成本处置将不再需要。第一阶段提案将：1。开发泵、阀门、仪器等，以组装现场可部署设备; 2.通过整合样品膜屏障和评估无害的替代内标物来优化我们的微芯片功能; 3.方法验证和现场测试。公共卫生关系：人类接触高氯酸盐是令人担忧的，因为可能损害甲状腺功能，导致一些发育迟缓和其他医疗问题。直到20世纪90年代后期，在开发出检测4 ppb水平的方法后，其在环境中的流行才引起了人们的兴趣。2005年，在被添加到环境保护局（EPA）的非管制污染物监测规则（UCMR 1）列表后，对2800个大型水系统和800个较小的系统（占美国所有水系统的不到10%）进行了抽样调查，发现25个州的153个地点受到污染。截至2005年，120个修复项目正在进行中，包括15个超级基金网站，耗资数亿美元的资金，主要来自政府金库。我们的在线监控设备将大大降低补救成本。除了降低现有补救措施的成本外，它还将允许较小的社区解决否则没有足够资源的清理问题。