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Human Apyrase to Disrupt Cancer Therapy

Human Apyrase to Disrupt Cancer Therapy
人类腺苷三磷酸双磷酸酶破坏癌症治疗
批准号：
7599772
负责人：
RIDONG CHEN
金额：
$19.67万
依托单位：
APT THERAPEUTICS, INC.
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
项目状态：
已结题
起止时间：
2008-09-12 至 2010-09-11
来源：
https://reporter.nih.gov/project-details/7599772
关键词：
AdhesionsAntiplatelet DrugsApyraseAspirinBiological AssayBleeding time procedureBloodBlood PlateletsBlood VesselsBody WeightBone PainBreastCancer PatientCause of DeathCell LineCell surfaceCellsCessation of lifeChinese Hamster Ovary CellClinicClinicalColorectal AdenomaColorectal CancerComputer AssistedCulture MediaCytotoxic ChemotherapyDiagnosisDiseaseDoseEndothelial CellsEndotheliumEndotoxinsEngineeringEnzymesExhibitsFatty acid glycerol estersFundingGenerationsGenesGliomaGoalsGrantGrowthGuanosine MonophosphateHalf-LifeHemorrhageHistologicHormone ReceptorHumanHydrolysisImmunocompetentIn VitroIncidenceInformaticsInvasiveLaboratoriesLeadLifeLuciferasesLungMalignant NeoplasmsMalignant neoplasm of prostateMammalian CellMammary glandMetastatic Neoplasm to the BoneModelingMusNeoplasm MetastasisOralOutcomePathway interactionsPatientsPharmaceutical PreparationsPhasePlatelet ActivationPlatelet Glycoprotein GPIIb-IIIa ComplexPlatelet aggregationPreclinical TestingPreventionProductionProphylactic treatmentProteinsPublic HealthRattusResearchRiskSafetySerumSubcutaneous InjectionsSystemTailTestingTimeTreatment ProtocolsTumor BurdenTumor-DerivedUnited StatesUniversitiesVeinsWashingtonadenomaaging populationcancer cellcancer therapyclinically relevantdayextracellularfluidityimprovedin vivoinhibitor/antagonistmalignant breast neoplasmmedical schoolsneoplastic cellnovelnovel therapeuticstherapeutic proteinvector

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英文摘要
DESCRIPTION (provided by applicant): Human apyrase represents a highly promising therapy for inhibition of cancer metastasis. The enzyme strongly inhibits platelet activation and aggregation without increasing bleeding risk. Using a protein informatics approach, we have successfully engineered an optimized human apyrase, APT102. With the Phase I grant support, we will determine whether APT102, alone or in combination with aspirin, is effective in inhibiting experimental spontaneous metastasis in mice. PUBLIC HEALTH RELEVANCE:Human apyrase represents a highly promising therapy for cancer treatment. We will determine whether the targeted apyrase, alone or in combination with aspirin, is effective in inhibiting experimental metastasis in mice.
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