腺苷三磷酸双磷酸酶辅助纤溶治疗-猫眼课题宝

腺苷三磷酸双磷酸酶辅助纤溶治疗

批准号：

7744087

负责人：

RIDONG CHEN

金额：

$22.61万

依托单位：

APT THERAPEUTICS, INC.

依托单位国家：

美国

项目类别：

财政年份：

2009

资助国家：

美国

项目状态：

已结题

起止时间：

2009-08-07 至 2011-07-31

来源：

https://reporter.nih.gov/project-details/7744087

关键词：

ADP Receptors ATP Hydrolysis Activated Partial Thromboplastin Time measurement Acute Acute myocardial infarction Adenosine Adhesions Alteplase Animal Model Animals Anti-Inflammatory Agents Anti-inflammatory Anticoagulants Antiplatelet Drugs Apyrase Arterial Fatty Streak Arteries Aspirin Awareness Binding Proteins Bleeding time procedure Blood Platelets Blood flow Canis familiaris Cause of Death Cell Culture Techniques Cell Line Cell surface Cerebral hemisphere hemorrhage Cessation of life Chinese Hamster Ovary Cell Clinic Computer Assisted Coronary Coronary Artery Bypass Coronary Thrombosis Coronary artery Culture Media Developed Countries Effectiveness Emergency Situation Engineering Enzymes Event Exhibits Experimental Animal Model Fibrinolysis Fibrinolytic Agents Funding Generations Genes Goals Grant Hemorrhage Heparin Hospitals Human Human Engineering Hydrolysis Implant Incidence Infarction Informatics Laboratories Mammalian Cell Medical Modeling Monitor Myocardial Myocardial Infarction Myocardial Reperfusion Myocardial tissue Myocardium Neurologic Oral Oral mucous membrane structure Outcome Patients Perfusion Phase Phospholipids Platelet Activation Platelet aggregation Preclinical Testing Production Property Proteinase-Activated Receptors Proteins Recombinants Reperfusion Injury Risk Rupture Safety Serine Serum Shock from electric current Stroke Surface Survival Rate Symptoms System Testing Thrombin Thrombolytic Therapy Thrombosis Thrombus Treatment Protocols Universities Washington annexin A5 clinically relevant clopidogrel design experience extracellular improved intravenous administration intravenous injection large scale production meetings mortality novel prothrombinase complex public health relevance restoration therapeutic protein vector

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DESCRIPTION (provided by applicant): Human apyrase represents a highly promising therapy for treatment of acute myocardial infarction. This enzyme strongly inhibits platelet activation and aggregation with modest bleeding risk. Using a protein informatics approach, we have successfully engineered human apyrases which exhibit both antiplatelet and anti-inflammatory activities. With the Phase I grant support, we will determine whether optimized human apyrases, in combination with tPA, induce rapid and sustained coronary artery recanalization without increasing bleeding risk. PUBLIC HEALTH RELEVANCE: We will utilize a coronary thrombotic model in dogs to validate whether human apyrase more effectively improve coronary patency than clopidogrel without increasing bleeding risk.

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