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Adjunctive Use of Apyrase to Fibrinolytic Therapy

腺苷三磷酸双磷酸酶辅助纤溶治疗

基本信息

批准号：
7744087
负责人：
RIDONG CHEN
金额：
$ 22.61万
依托单位：
APT THERAPEUTICS, INC.
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-08-07 至 2011-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7744087
关键词：
ADP Receptors ATP Hydrolysis Activated Partial Thromboplastin Time measurement Acute Acute myocardial infarction Adenosine Adhesions Alteplase Animal Model Animals Anti-Inflammatory Agents Anti-inflammatory Anticoagulants Antiplatelet Drugs Apyrase Arterial Fatty Streak Arteries Aspirin Awareness Binding Proteins Bleeding time procedure Blood Platelets Blood flow Canis familiaris Cause of Death Cell Culture Techniques Cell Line Cell surface Cerebral hemisphere hemorrhage Cessation of life Chinese Hamster Ovary Cell Clinic Computer Assisted Coronary Coronary Artery Bypass Coronary Thrombosis Coronary artery Culture Media Developed Countries Effectiveness Emergency Situation Engineering Enzymes Event Exhibits Experimental Animal Model Fibrinolysis Fibrinolytic Agents Funding Generations Genes Goals Grant Hemorrhage Heparin Hospitals Human Human Engineering Hydrolysis Implant Incidence Infarction Informatics Laboratories Mammalian Cell Medical Modeling Monitor Myocardial Myocardial Infarction Myocardial Reperfusion Myocardial tissue Myocardium Neurologic Oral Oral mucous membrane structure Outcome Patients Perfusion Phase Phospholipids Platelet Activation Platelet aggregation Preclinical Testing Production Property Proteinase-Activated Receptors Proteins Recombinants Reperfusion Injury Risk Rupture Safety Serine Serum Shock from electric current Stroke Surface Survival Rate Symptoms System Testing Thrombin Thrombolytic Therapy Thrombosis Thrombus Treatment Protocols Universities Washington annexin A5 clinically relevant clopidogrel design experience extracellular improved intravenous administration intravenous injection large scale production meetings mortality novel prothrombinase complex public health relevance restoration therapeutic protein vector

项目摘要

DESCRIPTION (provided by applicant): Human apyrase represents a highly promising therapy for treatment of acute myocardial infarction. This enzyme strongly inhibits platelet activation and aggregation with modest bleeding risk. Using a protein informatics approach, we have successfully engineered human apyrases which exhibit both antiplatelet and anti-inflammatory activities. With the Phase I grant support, we will determine whether optimized human apyrases, in combination with tPA, induce rapid and sustained coronary artery recanalization without increasing bleeding risk. PUBLIC HEALTH RELEVANCE: We will utilize a coronary thrombotic model in dogs to validate whether human apyrase more effectively improve coronary patency than clopidogrel without increasing bleeding risk.

描述（由申请人提供）：人apyrase是一种非常有前途的治疗急性心肌梗死的疗法。这种酶强烈抑制血小板的激活和聚集，有适度的出血风险。利用蛋白质信息学方法，我们成功地设计了具有抗血小板和抗炎活性的人类apyrase。在I期临床试验的支持下，我们将确定优化的人用酶与tPA联合是否能在不增加出血风险的情况下诱导冠状动脉快速持续再通。公共卫生相关性：我们将利用狗的冠状动脉血栓形成模型来验证人用apyrase是否比氯吡格雷更有效地改善冠状动脉通畅而不增加出血风险。