Continuing Retrospective/Prospective Studies Based on Clinical Observation

基于临床观察的持续回顾性/前瞻性研究

• 批准号: 7550704
• 负责人: ARTHUR J MATAS
• 金额: $ 8.04万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7550704
• 关键词: Admission activity; Albuminuria; Biopsy; Bone Diseases; Cardiovascular Diseases; Clinical; Clinical Data; Computers; Data; Data Collection; Data Storage and Retrieval; Databases; End stage renal failure; Follow-Up Studies; Functional disorder; General Population; Histocompatibility Testing; Hypertension; Incidence; Infection; Kidney; Kidney Diseases; Kidney Transplantation; Life; Liver; Living Donor Liver Transplantation; Living Donors; Longitudinal Studies; Minnesota; Multivariate Analysis; Non-Insulin-Dependent Diabetes Mellitus; Operative Surgical Procedures; Outcome; Patients; Personal Satisfaction; Prospective Studies; Proteinuria; Quality of life; Rehabilitation therapy; Research Design; Right lobe of liver; Risk; Risk Factors; Series; Skin Cancer; Staining method; Stains; Subgroup; System; Thrombophilia; Transplant Recipients; Transplantation; Universities; base; cardiovascular risk factor; complement C4d; computerized; diabetic; follow-up; graft function; improved; innovation; kidney allograft; non-diabetic; prospective

This project consists of 49 subprojects, each of which comprises a separate question to be asked of our comprehensive computerized clinical data storage and retrieval systems. We have collected data on more than 5,700 kidney transplants performed at the University of Minnesota since 1968, and very comprehensive information on 3,600 patients transplanted since 1984. Multiple details (preoperative risk factors; tissue typing; the transplant admission and surgery; donor information; post transplant readmissions, rejections, biopsies, infections, and other complications; quality of life, rehabilitation) are available. New transplantas are entered prospectively; in addition, we are adding patients transplanted prior to 1984 into this database. Two types of studies are planned--retrospective and prospective. In some of these subprojects, data collection has been completed and analysis is planned. In others, long-term follow-up is required. Our computer database permits us to study transplant risk factors to an extent that has not previously been possible. The computer allows analysis of mini-series of subgroups of patients and/or multivariate analysis of the importance of risk factors. Among the most important of the subprojects are: A. Impact of "hypercoagulability" on graft loss; D. Is C4d staining helpful in interpreting renal allograft biopsies?; G. Outcome in relation to recipient risk factors; J. How can outcome be maximized for recipients with failing grafts?; R. Is long-term outcome improving for current recipients?; T. Skin cancer; U. Defining slow graft function; W. Relationship between bone disease and cardiovascular disease; X. Ongoing studies on nondirected donation; II. Risk factors in diabetic and non-diabetic recipients.

该项目由 49 个子项目组成，每个子项目都包含一个针对我们综合计算机化临床数据存储和检索系统提出的单独问题。我们收集了明尼苏达大学自 1968 年以来进行的 5,700 多例肾移植手术的数据，以及自 1984 年以来 3,600 名移植患者的非常全面的信息。提供多种详细信息（术前危险因素；组织分型；移植入院和手术；供者信息；移植后再入院、排斥、活检、感染和其他并发症；生活质量、康复）。前瞻性地输入新的移植物；此外，我们还将 1984 年之前移植的患者添加到该数据库中。计划进行两种类型的研究——回顾性研究和前瞻性研究。其中一些子项目已完成数据收集并计划进行分析。在其他情况下，长期随访 是必须的。我们的计算机数据库使我们能够以前所未有的程度研究移植风险因素。计算机允许对患者亚组的迷你系列进行分析和/或对危险因素的重要性进行多变量分析。其中最重要的子项目包括： A. “高凝状态”对移植物损失的影响； D. C4d 染色有助于解释肾同种异体移植物活检吗？ G. 与接受者风险因素相关的结果； J. 如何才能最大限度地提高移植失败受者的治疗效果？ R. 当前接受者的长期结果是否有所改善？ T.皮肤癌； U. 定义慢移植功能； W.骨病与心血管疾病的关系；十、正在进行的非定向捐赠研究；二.糖尿病和非糖尿病接受者的危险因素。