Pancreas Cancer Biospecimens Repository

胰腺癌生物样本库

• 批准号: 7550533
• 负责人: DANIEL D VON HOFF
• 金额: $ 76.02万
• 依托单位: TRANSLATIONAL GENOMICS RESEARCH INST
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7550533
• 关键词: Arizona; Aspirate substance; Blood; Blood specimen; Cancer Center; Cancerous; Clinical; Clinical Data; Collaborations; Collection; Communities; Computational Biology; Confidentiality; Data; Databases; Development; Drug or chemical Tissue Distribution; Ensure; Environmental Risk Factor; Equipment and supply inventories; Family history of; Freezing; Goals; Grant; Guidelines; Human; Informed Consent; Institutes; Institution; Internet; Liquid substance; Lymphocyte Harvest; Malignant neoplasm of pancreas; Medial; Medical; Medical center; Monitor; Nitrogen; Numbers; Operative Surgical Procedures; Pancreas; Pancreatic Diseases; Participant; Pathologic; Patients; Pattern; Peripheral Blood Mononuclear Cell; Play; Progress Reports; Quality Control; Reagent; Reproduction spores; Research; Research Personnel; Role; Sampling; Serum; Services; Specimen; Time; Tissue Banks; Tissues; Translational Research; Universities; Work; demographics; design; experience; isopentane; lymph nodes; neoplastic; pancreatic neoplasm; repository; research study; translational study; tumor

The Pancreas Cancer Biospecimens Repository (Core A) will provide investigators of this P01 with access to normal and neoplastic human pancreatic tissue, regional lymph nodes, tumor aspirates and blood from patients suffering from pre-cancerous and cancerous pancreatic diseases. Functions of the Core will include collection of tissues, clinical annotations, proper storage and distribution of tissue to investigators. The Core will play an essential role in ensuring adequate numbers of pancreatic specimens for translational research studies. Currently, under the GI SPORE Grant of the AZCC, pancreatic tumor specimens and blood products are to be collected within the Tucson medical community. The intent of Core A is not to duplicate the collection of these reagents, but rather to extend the number and diversity of available specimen types. Knowing the limitations of any single institute to collect ample numbers of specimens for research in pancreatic cancer, the Core has enlisted the collaboration of eight separate medical centers dealing with pancreatic diseases. These institutions will provide additional fresh specimens (cancerous and non-cancerous tissue, portions of regional lymph nodes, and blood products) that will be collected under Core A, creating a centralized repository of diverse pancreatic tissues and biospecimens for investigational studies. Human pancreatic tissue specimens (pancreatic cancer, normal pancreas, and pre-cancerous tissue) will be collected after immediate snap freezing in isopentane-cooled liquid nitrogen and also preserved in RNAlater". Portions of the regional lymph nodes collected at the time of surgical pancreatic exploration will be snap frozen or submitted in medial to allow harvesting of lymphocytes. Additionally, blood samples will be collected from each patient and separated into peripheral blood mononuclear cells and serum, which may be used for analysis. In collaboration with the GI SPORE investigators, specimens will be annotated in a shared database with regard to patient demographics, environmental risk, exposure, medical and family history and pathologic data. This comprehensive database will be developed in concert with the Pattern Analysis and Computational Biology Core (Core B). Additional blood samples and clinical progress reports will be obtained at 6 monthly intervals for two years. With appropriate confidentiality monitoring, information will be accessible via the Internet to the P01 researchers at the AZCC and participating institutions. Informed consent will be obtained for all participants according to NCI guidelines and with the approval of each institution's IRB.Distribution of specimens to investigators will be overseen and prioritized by the Pancreatic Bioresource Utilization Committee, which will be organized under this Core service.

胰腺癌生物样本资料库(核心A)将为这一P01的研究人员提供 正常人和肿瘤性人胰腺组织、区域淋巴结、肿瘤抽吸物和患者血液 患有癌前疾病和癌症的胰腺疾病。核心的职能将包括收集 组织、临床注释、组织的适当存储和分发给研究人员。核心将扮演一个 在确保有足够数量的胰腺标本用于转译研究方面起着至关重要的作用。目前， 根据AZCC的GI孢子赠款，将采集胰腺肿瘤标本和血液产品 在图森医疗界。核心A的意图不是复制这些试剂的集合， 而是为了扩大可用标本类型的数量和多样性。知道任何单一的 为了收集大量样本用于胰腺癌的研究，该中心已经招募了 八个处理胰腺疾病的独立医疗中心的合作。这些机构将提供 额外的新鲜标本(癌组织和非癌组织、部分区域淋巴结和血液 产品)，将在核心A下收集，创建一个多样化的胰腺组织和 用于调查研究的生物标记物。人胰腺组织标本(胰腺癌，正常 胰腺和癌前组织)将在异戊烷冷却的液体中立即快速冷冻后收集 氮气，也保存在RNAlater中。手术时收集的部分区域淋巴结 胰腺探查将被快速冷冻或在中间提交，以允许采集淋巴细胞。 此外，将从每个患者身上采集血液样本，并将其分离为外周血单核细胞 细胞和血清，可用于分析。与GI孢子调查员合作，标本 将在共享数据库中注解有关患者的人口统计、环境风险、暴露、 病史、家族史和病理资料。这一全面的数据库将与 模式分析和计算生物学核心(核心B)。补充血样与临床进展 报告将在两年内每6个月提交一次。在适当的保密监控下， AZCC的P01研究人员和参与机构将通过互联网获取信息。 所有参与者将根据NCI指南获得知情同意，并经每个参与者的批准 机构的IRB。向调查人员分发标本将由胰腺组织监督并优先处理 生物资源利用委员会，将在这一核心服务下组织。