BLOCKING VIRUS SPREAD BY DCS WITH CARRAGEENAN-BASED COMPOUNDS
BLOCKING VIRUS SPREAD BY DCS WITH CARRAGEENAN-BASED COMPOUNDS
批准号:
7562275
负责人:
Melissa J Robbiani
金额:
$7.16万
依托单位国家:
美国
项目类别:
财政年份:
2007
资助国家:
美国
项目状态:
已结题
起止时间:
2007-05-01 至 2008-04-30
关键词:
BiologyCD4 Positive T LymphocytesCarrageenanCell CommunicationCellsChromosome PairingComplexComputer Retrieval of Information on Scientific Projects DatabaseDataDendritic CellsDrug FormulationsEpithelial CellsEventFundingFutureGrantHIVHIV InfectionsHandImmunologicsIn VitroInfectionInstitutionInvestigationLeukocytesMacacaMovementMucous MembranePathway interactionsPhaseRageResearchResearch PersonnelResourcesSourceSurfaceSynapsesT-LymphocyteTestingTissuesUnited States National Institutes of HealthVaginaVirusWorkbasein vivoinhibitor/antagonistmicrobicidepathogenpreventsimian human immunodeficiency virustransmission process
中文摘要
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
Early events leading to HIV infection across the mucosa likely involve HIV capture by a wide variety of molecules on the surface of epithelial cells and leukocytes followed by infection of permissive target cells within the tissues. In studying this biology, we are focusing on the contribution of dendritic cells (DCs) and T cells to these events and exploring effective ways to block these complex events in vitro and in vivo. Earlier work confirmed that there are at least two phases of DC-driven transmission of virus to T cells one involves virus captured by (but not infecting) DCs that is handed directly over to the T cells and the other involves DC infection and the transmission of newly synthesized viruses. Virus captured by DCs is transmitted to CD4 T cells moving rapidly across the synapse naturally created between DCs and T cells. Inclusion of the fusion inhibitor reduces the amount of virus movement to the T cells, while increasing the amount of virus accumulating in the DCs. The immunologic and virologic consequences of this are under investigation. These data highlight how only blocking certain pathways of virus-DC interactions are suboptimal in preventing DC-driven HIV spread. As a result, additional studies are being performed to test the ability of more broad acting carrageenan-based formulations for their ability to impede the complex virus-cell interplay needed to facilitate transmission. Carrageenan-based microbicides are promising due to their wide rage of activity against HIV/SIV and other sexually transmitted pathogens. Carrageenans impair virus capture by DCs in vitro and block infection of permissive DC-T cell mixtures. Recent in vivo data revealed that macaques were protected against vaginal SHIV challenge by carrageenan-based microbicides. These data are encouraging for future application of carrageenan-based formulations in preventing HIV spread.
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A novel vaginal ring to prevent HIV and HSV-2 infection, as well as pregnancy
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批准号:8450072
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项目类别:
-
资助金额:$19.42万
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财政年份:2012
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负责人:Melissa J Robbiani
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依托单位:
A novel vaginal ring to prevent HIV and HSV-2 infection, as well as pregnancy
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批准号:8264696
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项目类别:
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资助金额:$23.05万
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财政年份:2012
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负责人:Melissa J Robbiani
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依托单位:
HIV ENVELOPE SPECIFIC DARPIN-BASED MICROBICIDE
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批准号:8358133
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项目类别:
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资助金额:$5.78万
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财政年份:2011
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负责人:Melissa J Robbiani
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依托单位:
ZCM:A NOVEL BROAD-SPECTRUM MICROBICIDE FOR SEXUALLY TRANSMITTED INFECTIONS
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批准号:8358089
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项目类别:
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资助金额:$5.78万
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财政年份:2011
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负责人:Melissa J Robbiani
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依托单位:
IMPACT OF ART ON DC & TREG RESPONSES
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批准号:8358115
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项目类别:
-
资助金额:$5.78万
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财政年份:2011
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负责人:Melissa J Robbiani
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依托单位:
BLOCKING VIRUS SPREAD BY DCS WITH CARRAGEENAN-BASED COMPOUNDS
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批准号:8358043
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项目类别:
-
资助金额:$5.78万
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财政年份:2011
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负责人:Melissa J Robbiani
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依托单位:
DENDRITIC CELL ACTIVATION BY ISS ODN FOR SIV IMMUNITY
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批准号:8358061
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项目类别:
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资助金额:$5.78万
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财政年份:2011
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负责人:Melissa J Robbiani
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依托单位:
THE MUCOSAL DENDRITIC CELL-T CELL MILIEU AND SIV SPREAD
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批准号:8358075
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项目类别:
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资助金额:$5.78万
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财政年份:2011
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负责人:Melissa J Robbiani
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依托单位:
HIV ENVELOPE SPECIFIC DARPIN-BASED MICROBICIDE
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批准号:8173046
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项目类别:
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资助金额:$6.18万
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财政年份:2010
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负责人:Melissa J Robbiani
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依托单位:
ZCM:A NOVEL BROAD-SPECTRUM MICROBICIDE FOR SEXUALLY TRANSMITTED INFECTIONS
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批准号:8172989
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项目类别:
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资助金额:$6.18万
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财政年份:2010
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负责人:Melissa J Robbiani
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依托单位:
THE MUCOSAL DENDRITIC CELL-T CELL MILIEU AND SIV SPREAD
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批准号:8172970
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项目类别:
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资助金额:$6.18万
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财政年份:2010
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负责人:Melissa J Robbiani
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依托单位:
DENDRITIC CELL ACTIVATION BY ISS ODN FOR SIV IMMUNITY
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批准号:8172955
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项目类别:
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资助金额:$6.18万
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财政年份:2010
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负责人:Melissa J Robbiani
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依托单位:
BLOCKING VIRUS SPREAD BY DCS WITH CARRAGEENAN-BASED COMPOUNDS
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批准号:8172934
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项目类别:
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资助金额:$6.18万
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财政年份:2010
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负责人:Melissa J Robbiani
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依托单位:
IMPACT OF ART ON DC & TREG RESPONSES
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批准号:8173027
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项目类别:
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资助金额:$6.18万
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财政年份:2010
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负责人:Melissa J Robbiani
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依托单位:
BLOCKING VIRUS SPREAD BY DCS WITH CARRAGEENAN-BASED COMPOUNDS
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批准号:7958592
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项目类别:
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资助金额:$5.81万
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财政年份:2009
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负责人:Melissa J Robbiani
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依托单位:
IMPACT OF ART ON DC & TREG RESPONSES
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批准号:7958720
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项目类别:
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资助金额:$5.81万
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财政年份:2009
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负责人:Melissa J Robbiani
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依托单位:
HIV-envelope-specific DARPin-based microbicide strategies
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批准号:8313900
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项目类别:
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资助金额:$69.44万
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财政年份:2009
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负责人:Melissa J Robbiani
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依托单位:
HIV-envelope-specific DARPin-based microbicide strategies
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批准号:7737766
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项目类别:
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资助金额:$48.84万
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财政年份:2009
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负责人:Melissa J Robbiani
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依托单位:
ZCM:A NOVEL BROAD-SPECTRUM MICROBICIDE FOR SEXUALLY TRANSMITTED INFECTIONS
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批准号:7958669
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项目类别:
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资助金额:$3.63万
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财政年份:2009
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负责人:Melissa J Robbiani
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依托单位:
HIV-envelope-specific DARPin-based microbicide strategies
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批准号:8134855
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项目类别:
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资助金额:$74.53万
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财政年份:2009
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负责人:Melissa J Robbiani
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依托单位: