EVALUATION OF CELLULAR IMMUNITY INDUCED BY HIV VACCINES

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The mission of the HIV Vaccine Trials Network is to develop and test the efficacy of candidate HIV Vaccines. The Central Immunology Laboratory (CIL) of the HVTN is responsible for assessment of immune responses induced by those vaccines in human subjects. The CIL has established a number of satellite laboratories called "Special Emphasis Groups" for the purposes of developing and validating novel assays of T cell function. The role of the laboratory in this project is to develop novel MHC tetramer reagents based upon a large panel of HLA alleles and the epitopes presented by those alleles in candidate vaccines, and to validate the use of these reagents in the evaluation of human clinical trials.effective communication within the laboratory network as well as between the CL and various functional units of the HVTN.