EMORY CONTE CENTER FOR THE NEUROSCIENCE OF MENTAL DISORDERS: PRIMATE CORE

埃默里孔特精神障碍神经科学中心：灵长类核心

• 批准号: 7562509
• 负责人: MAR SANCHEZ
• 金额: $ 3.16万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7562509
• 关键词: Adolescence; Adolescent; Adrenal Glands; Age; Alleles; Animals; Behavior; Body Weight; Circadian Rhythms; Computer Retrieval of Information on Scientific Projects Database; Corticotropin; Data Collection; Dental crowns; Development; Emotional; Epigenetic Process; Exhibits; Female; Funding; Genes; Goals; Grant; Growth; HPSE gene; Heel; Height; Hydrocortisone; Infant; Institution; Length; Leptin; Life Stress; Long-Term Effects; Macaca mulatta; Measures; Mental disorders; Metabolism; Modeling; Monkeys; Neurosciences; Phenotype; Pituitary Gland; Plasma; Polysomnography; Primates; Promoter Regions; Purpose; Rate; Reporting; Research; Research Personnel; Resources; Sampling; Sleep; Social Behavior; Somatotropin; Source; Stress; United States National Institutes of Health; Work; actigraphy; base; bone; ghrelin; hypothalamic-pituitary-adrenal axis; maternal separation; monoamine; nonhuman primate; response; serotonin transporter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Emory Conte Center for the Neuroscience of Mental Disorders - Primate Core. The major goal of this work has been to produce and characterize a non-human primate epigenetic early life stress model in rhesus monkeys. The purpose is to provide, maintain and characterize phenotypes of monkeys with an early developmental stress. We have investigated the short-term and long-term effects of repeated maternal separation on emotional behavior and HPA axis function of the animals. We previously reported that repeated maternal separations sensitized the infants' HPA axis responses to stress, particularly in females and infants with the short allele of the promoter region of the serotonin transporter gene (rh5-HTTLPR). As juveniles, maternally-separated subjects exhibited enhanced startle reactivity, flattened cortisol diurnal rhythms and alterations in pituitary-adrenal function detected with CRF and ACTH pharmacological challenges. Progress this year included the continued collection of data for longitudinal analyses of: a) HPA and HPT axes function at later ages (juvenile-adolescence), detecting sensitized cortisol responses to stress after habituation paradigms; b) CSF levels of monoamine metabolites and CRF; c) Physical growth and metabolism: every 6 months we are collecting measures of height (crown-rump, crown-heel length), body weight, BMI, bone maturity (rated from radiographs), as well as plasma samples for measures of growth hormone, leptin, ghrelin, etc; d) Sleep and activity: using activity-based sleep monitoring (actigraphy); e) Social behavior; and f) Serotonergic function.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 Emory Conte Center for the Neuroscience of Mental Disorders（英语：Emory Conte Center for the Neuroscience of Mental Disorders） 这项工作的主要目标是在恒河猴中产生和表征非人灵长类表观遗传早期生活应激模型。 目的是提供、维持和表征具有早期发育应激的猴的表型。我们研究了反复的母亲分离对动物情绪行为和HPA轴功能的短期和长期影响。我们以前曾报道，反复的母亲分离敏感的婴儿的HPA轴反应的压力，特别是在女性和婴儿的5-羟色胺转运蛋白基因（rh 5-HTTLPR）的启动子区的短等位基因。作为青少年，母亲分离的主题表现出增强惊吓反应，平坦的皮质醇昼夜节律和垂体肾上腺功能的变化与CRF和ACTH药理学挑战检测。本年度的进展包括继续收集数据进行纵向分析：a）HPA和HPT轴在较晚年龄的功能（青少年-青春期），检测习惯化范例后对应激的致敏皮质醇反应; B）单胺代谢物和CRF的CSF水平; c）身体生长和代谢：每六个月我们都会收集（顶臀、顶踵长度）、体重、BMI、骨成熟度（根据放射照片评定），以及用于测量生长激素、瘦素、生长激素释放肽等的血浆样品; d）睡眠和活动：使用基于活动的睡眠监测（活动记录）; e）社会行为;和f）血清素能功能。