Identification and erradication of pre-malignant B cells in the prevention of lymphoma

识别并根除癌前 B 细胞以预防淋巴瘤

• 批准号: nhmrc : 1085156
• 负责人: Dr Dimitra Zotos
• 金额: $ 40.53万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identification-erradication-pre-prevention-lymphoma/519065
• 关键词: Identification; erradication; pre; malignant; cells

B Cell Lymphoma is the most frequent type of non-Hodgkin lymphoma in adults and despite improved treatment, 40-50% of patients succumb to their disease. T cells are critical in the in the prevention B cell lymphoma development. In this project we aim to identify the earliest stages of B cell lymphoma and mechanisms of escape from T cell control with the ultimate aim to translate these findings to human studies to improve disease diagnosis, treatment and prognosis.

B 细胞淋巴瘤是成人中最常见的非霍奇金淋巴瘤类型，尽管治疗有所改善，但 40-50% 的患者仍死于该病。 T 细胞对于预防 B 细胞淋巴瘤的发展至关重要。在这个项目中，我们的目标是确定 B 细胞淋巴瘤的最早阶段以及逃离 T 细胞控制的机制，最终目标是将这些发现转化为人体研究，以改善疾病的诊断、治疗和预后。