IL21, B-cell Proliferation and the Mechanism of Memory Formation

IL21、B 细胞增殖和记忆形成机制

• 批准号: nhmrc : 1146617
• 负责人: Dr Dimitra Zotos
• 金额: $ 65.47万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/il21-b-cell-memory-formation/1320691
• 关键词: IL21; cell; Proliferation; Mechanism; Memory

Our immune system can ‘remember’ old infections, which is why we do not suffer from the same pathogen multiple times and why vaccines work. Much of this protection is due to memory B-cells, of which there are different kinds. We think the different memory B-cell subsets have different functions and understanding how they are made and how this is controlled will help us improve responses to critical infections – HIV, Flu – and in critical patient groups – aged people and transplant recipients.

我们的免疫系统可以“记住”旧的感染，这就是为什么我们不会多次遭受相同的病原体，也是为什么疫苗有效。这种保护在很大程度上是由于记忆B细胞，其中有不同的种类。我们认为不同的记忆B细胞亚群具有不同的功能，了解它们是如何产生的以及如何控制它们将有助于我们改善对严重感染的反应-艾滋病毒，流感-以及危重患者群体-老年人和移植受体。