Core--Animal Experimentation

核心——动物实验

• 批准号: 6892955
• 负责人: JONATHAN CHEN
• 金额: $ 52.54万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6892955
• 关键词: auxiliary heart prosthesis; biomedical facility; congestive heart failure; coronary bypass; disease /disorder model; dogs; heart disorder chemotherapy; heart surgery; laboratory mouse; laboratory rat; medical implant science; model design /development; nonhuman therapy evaluation; swine

The function of the animal experimentation core unit is to provide the in vivo experiments (themselves based upon prior in vitro work) on which later human application may be based. Accordingly, the purpose of the animal experimentation core is threefold, and seeks to address the individual investigations of the SCCOR regarding: 1) coagulation, 2) infection, and 3) cellular transplantation in the setting of long-term mechanical circulatory support. To accomplish these goals, several species will be required, including rodent, canine and porcine models, each chosen for specific physiologic and anatomic advantages for use in the given sub-investigation. Consequently, the overall animal experimentation involves both survival and non-survival experiments, and ultimately attempts to mimic the human condition for later application. The personnel involved reflect the expertise required at each level therein.

动物实验核心单元的功能是提供体内实验（本身基于先前的体外工作），随后的人类应用可能基于体内实验。因此，动物实验核心的目的是三重的，并寻求解决SCCOR的个体调查：1)凝血，2)感染，3)长期机械循环支持环境下的细胞移植。为了实现这些目标，将需要几个物种，包括啮齿动物、犬和猪模型，每个物种都有特定的生理和解剖优势，用于给定的子调查。因此，整个动物实验包括生存和非生存实验，并最终试图模仿人类的条件，以供以后应用。所涉人员反映了其中每一级所需的专门知识。