Core--Animal Experimentation

动物实验核心单元的功能是提供体内实验(它们本身基于先前的体外工作)，以供以后的人类应用。因此，动物实验核心的目的有三个方面，并试图解决SCCOR关于以下方面的个别研究：1)凝血，2)感染，3)长期机械循环支持下的细胞移植。为了实现这些目标，将需要几个物种，包括啮齿动物、犬类和猪模型，每个物种都选择特定的生理和解剖优势用于给定子调查。因此，整个动物实验既包括生存实验，也包括非生存实验，最终试图模拟人类的情况，以便以后应用。所涉人员反映了其中每个级别所需的专门知识。

The function of the animal experimentation core unit is to provide the in vivo experiments (themselves based upon prior in vitro work) on which later human application may be based. Accordingly, the purpose of the animal experimentation core is threefold, and seeks to address the individual investigations of the SCCOR regarding: 1) coagulation, 2) infection, and 3) cellular transplantation in the setting of long-term mechanical circulatory support. To accomplish these goals, several species will be required, including rodent, canine and porcine models, each chosen for specific physiologic and anatomic advantages for use in the given sub-investigation. Consequently, the overall animal experimentation involves both survival and non-survival experiments, and ultimately attempts to mimic the human condition for later application. The personnel involved reflect the expertise required at each level therein.