ANTI-OVARIAN CANCER PROPERTIES OF RU-486

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 卡洛斯泰莱里亚博士的实验室正在研究合成类固醇米非司酮（也称为RU-486）的抗卵巢癌特性。 抗癌症活性与避孕特性（米非司酮）完全无关。 这些研究是该药物标签外用药的临床前研究。 这种药物对其他医学疾病的效用一直未得到充分探索，并受到反堕胎政治的危害。 实验室研究的总体目标是研究利用这种最初用于避孕目的的合成类固醇治疗卵巢癌的可行性。 来自Telleria博士实验室的实验，得到了SD BRIN试点赠款的支持，最近发表在2007年6月1日的《临床癌症研究》杂志上。他们揭示了米非司酮是一种有效的卵巢癌生长抑制剂，利用培养的人卵巢癌细胞和携带卵巢癌疾病的小鼠进行了证明。米非司酮对卵巢癌的生长抑制作用与其抗孕激素活性无关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The laboratory of Dr. Carlos Telleria is studying the anti-ovarian cancer properties of the synthetic steroid mifepristone, also known as RU-486. The anti-cancer activity is totally unrelated to the contraceptive properties (of mifepristone). These studies are pre-clinical studies of off-label uses for this drug. The utility of this drug for other medical illnesses has been underexplored and jeopardized by anti-abortion politics. The overall goal of the research in the laboratory is to study the feasibility of utilizing this synthetic steroid, originally designed for contraceptive purposes, for the treatment of ovarian cancer. Experiments from Dr. Telleria's laboratory, which have been supported through SD BRIN pilot grants, have recently been published in the June 1, 2007 issue of Clinical Cancer Research. They reveal that mifepristone is a potent inhibitor of the growth of ovarian cancer, demonstrated utilizing human ovarian cancer cells maintained in culture and mice carrying ovarian cancer disease. The growth inhibition effect of mifepristone for ovarian cancer is not related to the antiprogesterone activity that claims its contraceptive properties.