DEVELOPMENTAL CHANGES IN CORPUS LUTEUM

黄体的发育变化

• 批准号: 7610301
• 负责人: Carlos Marcelo Telleria
• 金额: $ 3.24万
• 依托单位: UNIVERSITY OF SOUTH DAKOTA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7610301
• 关键词: Apoptosis; Area; Arts; Cancer Etiology; Cause of Death; Cell Death; Cells; Cessation of life; Computer Retrieval of Information on Scientific Projects Database; Development; Functional disorder; Funding; Gene Expression; Goals; Grant; In Vitro; Infertility; Institution; Laboratories; Malignant Neoplasms; Malignant neoplasm of ovary; Molecular; Ovarian; Physiological; Pregnancy loss; Progesterone; Research; Research Personnel; Resources; Source; Steroids; Techniques; United States National Institutes of Health; Woman; corpus luteum; in vivo; peptide hormone

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The major area of research undertaken in Dr. Telleria's laboratory deals with the molecular mechanisms by which steroid and peptide hormones control function, survival and physiological death (apoptosis) of ovarian cells. In vivo, ex-vivo and in-vitro experimental approaches are used combined with state-of-the-art techniques for the study of apoptosis and gene expression. The ultimate goal is to understand the mechanisms of ovarian cell death to be able to: i) reestablish function in cases of infertility caused by luteal dysfunction and corpus luteum inadequacy, in which the primary problem is the insufficient quantity or duration of progesterone secretion that leads to repetitive pregnancy losses; and ii) accelerate cell death in the case of ovarian cancer, which is the fourth most frequent cause of cancer death among women and the leading cause of death from gynecological malignancies.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 Telleria 博士实验室的主要研究领域涉及类固醇和肽激素控制卵巢细胞功能、存活和生理死亡（细胞凋亡）的分子机制。体内、离体和体外实验方法与最先进的技术相结合，用于细胞凋亡和基因表达的研究。最终目标是了解卵巢细胞死亡的机制，以便能够：i）在黄体功能障碍和黄体不足引起的不孕症中重建功能，其中主要问题是黄体酮分泌量或持续时间不足，导致反复妊娠失败； ii) 加速卵巢癌的细胞死亡，卵巢癌是女性癌症死亡的第四大常见原因，也是妇科恶性肿瘤死亡的主要原因。