CELEGANS AS A MODEL TO STUDY VIRAL ANTI-APOPTOTIC GENES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们的长期目标是利用模式生物秀丽线虫来详细了解糖肽激素信号的组成、调节和生物学功能。我们成熟的研究结果揭示了FSHR-1的几个关键的生殖功能，FSHR-1是线虫FSH/LH/TSH受体的祖先同源基因，包括在诱导卵母细胞发育、维持生殖系干细胞种群以及通过抑制凋亡促进生殖细胞存活等方面发挥作用。该项目的目标是开发可用于识别FSHR-1信号的下游和辅助成分的遗传方法。对线虫的研究有望为揭示调节糖肽激素信号转导的保守和新颖的因子提供有效的手段。我们对线虫发育生物学和遗传学的广泛知识以及我们非常广泛的初步结果，使我们处于成功完成我们特定目标的极佳地位。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our long-term goal is to gain a detailed understanding of the components, regulation, and biological functions of glycopeptide hormone signaling using the model organism C. elegans. Our well-developed findings have revealed several key reproductive functions for FSHR-1, the C. elegans ancestral ortholog of the FSH/LH/TSH receptor, including roles in the induction of oocyte development, maintenance of the germline stem cell population, and the promotion of germ cell survival through the inhibition of apoptosis. The goal of this project is to develop genetic approaches that can be used to identify the downstream and accessory components of FSHR-1 signaling. It is expected that studies in C. elegans will provide a potent and efficient means for uncovering conserved and novel factors that mediate the transduction of glycopeptide hormone signaling. Our broad knowledge of C. elegans developmental biology and genetics as well as our very extensive preliminary results, place us in an excellent position for the successful completion of our specific aims.