COBRE PROJ 9: STRUCTURE-ACTIVITY ANALYSIS OF TISSUE-SPECIFIC CARCINOGENS

COBRE 项目 9：组织特异性致癌物的结构活性分析

• 批准号: 7720770
• 负责人: ALBERT R CUNNINGHAM
• 金额: $ 21.72万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7720770
• 关键词: Attributes of Chemicals; Carcinogens; Chemicals; Computer Retrieval of Information on Scientific Projects Database; Etiology; Funding; Genomics; Grant; Institution; Modeling; Molecular Target; Proteomics; Research; Research Personnel; Resources; Source; Specificity; Structure; Structure-Activity Relationship; Tissues; United States National Institutes of Health; carcinogenesis; chemical carcinogen; chemical carcinogenesis; drug discovery; novel therapeutics; therapeutic target

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Albert Cunningham, PI Dr. Albert Cunningham, who arrived on April 1, 2007, has finalized his project description, which includes the specific aims of discovering molecular targets of chemical carcinogens that (1) can be used to study the etiology of tissue-specific chemical carcinogenesis and (2) can also serve as potentially new therapeutic targets for drug discovery. He concurrently employs computational structure-activity relationship modeling and proteomic/genomic analyses to look at chemical carcinogens with differing tissue specificity in order to accomplish two things: first, to identify structural attributes of chemical carcinogens associated with tissue-specific carcinogenesis; second, to use these attributes as chemical probes to search for tissue-specific molecular targets associated with chemical carcinogenesis.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 Albert Cunningham，PI Albert Cunningham博士于2007年4月1日抵达，他已经完成了他的项目描述，其中包括发现化学致癌物的分子靶点的具体目标，（1）可用于研究组织特异性化学致癌作用的病因学，（2）也可以作为药物发现的潜在新治疗靶点。 他同时采用计算结构-活性关系建模和蛋白质组学/基因组学分析来研究具有不同组织特异性的化学致癌物，以完成两件事：第一，确定与组织特异性致癌相关的化学致癌物的结构属性;第二，使用这些属性作为化学探针来搜索与化学致癌相关的组织特异性分子靶点。