COBRE PROJ 9: STRUCTURE-ACTIVITY ANALYSIS OF TISSUE-SPECIFIC CARCINOGENS

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Progress Report Summary: Dr. Albert Cunningham, who arrived on April 1, 2007, is finalizing his project description, which has the specific aims of discovering molecular targets of chemical carcinogens that (1) can be used to study the etiology of tissue-specific chemical carcinogenesis and (2) can also serve as potentially new therapeutic targets for drug discovery. He will concurrently employ computational structure-activity relationship modeling and proteomic/genomic analyses to look at chemical carcinogens with differing tissue specificity in order to first identify structural attributes of chemical carcinogens associated with tissue-specific carcinogenesis and then using these attributes as chemical probes to search for tissue specific molecular targets associated with chemical carcinogenesis.