COBRE PROJ 9: STRUCTURE-ACTIVITY ANALYSIS OF TISSUE-SPECIFIC CARCINOGENS

COBRE 项目 9：组织特异性致癌物的结构活性分析

• 批准号: 7610542
• 负责人: ALBERT R CUNNINGHAM
• 金额: $ 22.32万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7610542
• 关键词: Attributes of Chemicals; Carcinogens; Chemicals; Computer Retrieval of Information on Scientific Projects Database; Etiology; Funding; Genomics; Grant; Institution; Modeling; Molecular Target; Progress Reports; Proteomics; Research; Research Personnel; Resources; Source; Specificity; Structure; Structure-Activity Relationship; Summary Reports; Tissues; United States National Institutes of Health; carcinogenesis; chemical carcinogen; chemical carcinogenesis; drug discovery; novel therapeutics; therapeutic target

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Progress Report Summary: Dr. Albert Cunningham, who arrived on April 1, 2007, is finalizing his project description, which has the specific aims of discovering molecular targets of chemical carcinogens that (1) can be used to study the etiology of tissue-specific chemical carcinogenesis and (2) can also serve as potentially new therapeutic targets for drug discovery. He will concurrently employ computational structure-activity relationship modeling and proteomic/genomic analyses to look at chemical carcinogens with differing tissue specificity in order to first identify structural attributes of chemical carcinogens associated with tissue-specific carcinogenesis and then using these attributes as chemical probes to search for tissue specific molecular targets associated with chemical carcinogenesis.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 进展报告摘要：阿尔伯特·坎宁安博士于2007年4月1日抵达，他正在最后敲定他的项目描述，该项目的具体目标是发现化学致癌物的分子靶点，这些分子靶点(1)可用于研究组织特异性化学致癌的病因学，(2)也可用作药物发现的潜在新治疗靶点。他将同时使用计算结构-活性关系建模和蛋白质组/基因组分析来寻找具有不同组织特异性的化学致癌物，以便首先确定与组织特异性致癌相关的化学致癌物的结构属性，然后将这些属性用作化学探针，以寻找与化学致癌相关的组织特异性分子靶标。