COBRE P5: RELATIONSHIP BETWEEN PERIODONTAL DISEASE AND TYPE 2 DIABETES

COBRE P5：牙周疾病与 2 型糖尿病之间的关系

• 批准号: 7720806
• 负责人: RENATA LEITE
• 金额: $ 12.73万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7720806
• 关键词: Admixture; African American; Computer Retrieval of Information on Scientific Projects Database; Diabetes Mellitus; Disease Progression; Funding; Genetic; Glycosylated hemoglobin A; Grant; Institution; Island; Life; Neutrophil Collagenase; Non-Insulin-Dependent Diabetes Mellitus; Patients; Periodontal Diseases; Population; Purpose; Research; Research Personnel; Research Project Grants; Resources; Sea; Source; South Carolina; Testing; United States National Institutes of Health; diabetic; glycemic control

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this research project is to test the hypothesis that treatment of periodontal disease is associated with better diabetes glycemic control (HbA1c) and lower levels of the catalytically active form of MMP-8 in the Gullah-speaking African American patients. We will conduct an interventional study on this population with minimal genetic admixture, living on the Sea Islands of the South Carolina coast. There are three specific aims. The first aim will demonstrate that periodontal disease progression on poorly controlled Type 2 diabetic Gullah patients is more severe than on well-controlled patients. The second aim will assess the effects of periodontal therapy on the level of glycemic control in the Gullah population. The third aim will assess the concentration of the catalytically active form of MMP-8 at baseline (prior to periodontal intervation) and 3 and 6 months later.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究项目的目的是验证这样一个假设，即牙周病的治疗与较好的糖尿病血糖控制(HbA1c)和较低水平的催化活性形式的基质金属蛋白酶-8在古拉语非裔美国患者中相关。我们将对居住在南卡罗来纳州海岸的海洋群岛上的这一种群进行最小程度的遗传混合的干预性研究。有三个具体目标。第一个目标将证明控制不良的2型糖尿病Gullah患者的牙周疾病进展比控制良好的患者更严重。第二个目标是评估牙周治疗对古拉族人群血糖控制水平的影响。第三个目标将评估基线(牙周介入前)以及3个月和6个月后的催化活性形式的基质金属蛋白酶-8的浓度。