PERIODONTAL DISEASES AND TYPE 2 DIABETES MELLITUS IN THE GULLAH POPULATION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在过去的十年左右，关于牙周状况和糖尿病控制的关系，许多研究得出了模棱两可的结果。目前有一项由Cochrane合作编写的议定书，旨在解决糖尿病患者控制血糖的牙周病治疗问题。拟议中的研究假设治疗 牙周病将产生更好的糖尿病血糖控制和降低 古拉族非裔美国糖尿病患者体内基质金属蛋白酶-8的催化活性形式 南卡罗来纳州海岸的一个海岛。这项研究包括以前在古拉地区进行的为期5年的牙周病研究的人群(J·费尔南德斯博士)，以及其他古拉族参与者。其具体目的是：1)确定与控制良好的非裔美国人相比，控制不佳的2型糖尿病患者的牙周疾病进展速度；2)评估牙周治疗对这一人群血糖控制水平的影响；以及3)评估催化活性形式的基质金属蛋白酶-8的浓度。在以前的研究中，只研究了基质金属蛋白酶-8，而没有研究其催化活性形式。这项研究的知识可能会导致开发一种治疗策略来减缓牙周病的进展，甚至可能防止牙周病在这一人群中的发病。此外，人们还希望找到一种牙周病活动性生物标志物(活性基质金属蛋白酶-8)，它将只指导那些患有活动性疾病的患者进行治疗，从而节省大量的时间和费用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. For the past decade or so, numerous studies have produced equivocal results concerning the relationship of periodontal status and diabetes control. Currently there is a Protocol written from the Cochrane Collaboration to address the question of Treatment of periodontal disease for glycaemic control in people with diabetes. The proposed study hypothesizes that the treatment of periodontal disease will produce better diabetes glycemic control and reduced levels of the catalytically active form of MMP-8 in the Gullah African American diabetes patients living on the Sea Islands of the South Carolina coast. The study includes the population of the previous 5-year study of periodontal disease in the Gullah (Dr. J. Fernandes) and also additional Gullah participants. The specific aims are 1) to ascertain the rate of periodontal disease progression on poorly controlled type 2 diabetic Gullah African American patients as compared to well controlled African American Patients, 2) to assess the effects of periodontal therapy on the level of glycemic control in this population, and 3) to assess the concentration of the catalytically active form of MMP-8. In the previous study only MMP-8 was studied and not the catalytically active form. The knowledge from this study can potentially lead to development of a therapeutic strategy to reduce periodontal disease progression and maybe even prevent periodontal disease onset in this population. Also there is hope to find a periodontal disease activity biomarker (active MMP-8) that would direct treatment to only those patients with active disease, saving significant time and expenses.