PERIODONTAL DISEASES AND TYPE 2 DIABETES MELLITUS IN THE GULLAH POPULATION

GULLAH 人群的牙周疾病和 2 型糖尿病

• 批准号: 7719629
• 负责人: RENATA LEITE
• 金额: $ 2.48万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719629
• 关键词: Address; African American; Biological Markers; Collaborations; Computer Retrieval of Information on Scientific Projects Database; Development; Diabetes Mellitus; Disease; Disease Progression; Funding; Grant; Institution; Island; Knowledge; Lead; Life; Neutrophil Collagenase; Non-Insulin-Dependent Diabetes Mellitus; Onset of illness; Participant; Patients; Periodontal Diseases; Population; Protocols documentation; Rate; Research; Research Personnel; Resources; Sea; Source; South Carolina; Therapeutic; Time; United States National Institutes of Health; Writing; diabetic; glycemic control; prevent

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. For the past decade or so, numerous studies have produced equivocal results concerning the relationship of periodontal status and diabetes control. Currently there is a Protocol written from the Cochrane Collaboration to address the question of Treatment of periodontal disease for glycaemic control in people with diabetes. The proposed study hypothesizes that the treatment of periodontal disease will produce better diabetes glycemic control and reduced levels of the catalytically active form of MMP-8 in the Gullah African American diabetes patients living on the Sea Islands of the South Carolina coast. The study includes the population of the previous 5-year study of periodontal disease in the Gullah (Dr. J. Fernandes) and also additional Gullah participants. The specific aims are 1) to ascertain the rate of periodontal disease progression on poorly controlled type 2 diabetic Gullah African American patients as compared to well controlled African American Patients, 2) to assess the effects of periodontal therapy on the level of glycemic control in this population, and 3) to assess the concentration of the catalytically active form of MMP-8. In the previous study only MMP-8 was studied and not the catalytically active form. The knowledge from this study can potentially lead to development of a therapeutic strategy to reduce periodontal disease progression and maybe even prevent periodontal disease onset in this population. Also there is hope to find a periodontal disease activity biomarker (active MMP-8) that would direct treatment to only those patients with active disease, saving significant time and expenses.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 在过去的十年左右，许多研究已经产生了关于牙周状况和糖尿病控制的关系模棱两可的结果。目前，科克伦协作组编写了一份方案，以解决糖尿病患者牙周病治疗的问题。 这项研究假设， 牙周病的治疗将更好地控制糖尿病血糖， 生活在美国的Gullah非裔美国糖尿病患者中MMP-8的催化活性形式 南卡罗来纳州海岸的海岛。该研究包括以前在Gullah（J. Fernandes博士）进行的为期5年的牙周病研究的人群以及其他Gullah参与者。具体目的是1）确定与控制良好的非裔美国人患者相比，控制不良的2型糖尿病Gullah非裔美国人患者的牙周病进展率，2）评估牙周治疗对该人群中血糖控制水平的影响，和3）评估MMP-8的催化活性形式的浓度。在先前的研究中，仅研究了MMP-8，而不是催化活性形式。这项研究的知识可能会导致开发一种治疗策略，以减少牙周病的进展，甚至可能预防牙周病在这一人群中的发病。也有希望找到一种牙周病活动性生物标志物（活性MMP-8），将直接治疗只有那些患者的活动性疾病，节省大量的时间和费用。