EFFECTS OF TAT EXPRESSION IN NEURAL PROGENITOR CELLS ON NEUROCOGNITIVE DYSFUNCTI

神经祖细胞中 TAT 表达对神经认知功能障碍的影响

• 批准号: 7720893
• 负责人: RUGAO LIU
• 金额: $ 3.96万
• 依托单位: UNIVERSITY OF NORTH DAKOTA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7720893
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Functional disorder; Funding; Grant; HIV-1; Institution; Lead; Mediating; Neurocognitive; Nuclear Pore Complex; Research; Research Personnel; Research Proposals; Resources; Source; Testing; Transgenic Organisms; United States National Institutes of Health; mouse model; nerve stem cell; selective expression; tat Protein

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The major hypothesis of the research proposal is that selective expression of Tat in NPCs may alter the proliferation, differentiation and survival of NPCs in the CNS, which may lead to neurocognitive dysfunction, similar to HIV-1-mediated HAD. The following aims will be performed to test the hypothesis: 1) To establish a mouse model of selective expression of HIV-1 Tat protein in NPCs, and to study the effect of Tat expression on NPC proliferation, differentiation and survival. 2) To study and validate the effects of Tat expression in NPCs on neurocognitive function (dysfunction) in the transgenic mouse model recapitulating HIV-1-mediated HAD.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该研究方案的主要假设是，达特在NPC中的选择性表达可能改变CNS中NPC的增殖、分化和存活，这可能导致神经认知功能障碍，类似于HIV-1介导的HAD。 1）建立选择性表达HIV-1达特蛋白的NPC小鼠模型，研究达特蛋白表达对NPC增殖、分化和存活的影响。2)研究和验证达特基因在NPC中的表达对复制HIV-1介导的HAD的转基因小鼠模型的神经认知功能（功能障碍）的影响。