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Functional analysis of the neuronal network in patients with functional disorder of basal ganglia using non-invasive neurotransmitter imaging

使用无创神经递质成像对基底节功能障碍患者的神经网络进行功能分析

基本信息

批准号：
17591525
负责人：
SASAJIMA Hiroyasu
金额：
$ 2.18万
依托单位：
Kyoto Prefectural University of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2006
项目状态：
已结题

项目摘要

The basal ganglia are undoubtedly among the most complex and least understood structures in the mammalian forebrain. In this study, we evaluated phosphoinositide turnover in the cerebrum and dopamine metabolism in the basal ganglia using ^<11>C-diacylglycerol-positron emission computed tomography (PET) and ^<18>F-fluorodopa-PET in patients with functional disorder of basal ganglia before and after treatment.^<11>C-diacylglycerol-PET of Parkinson's disease showed acceleration of the phosphoinositide turnover of the bilateral striatum and functional supression of the ipsilateral thalamus. These results indicate the superiority of the indirect pathway through subthalamic nucleus in patients with Parkinson's disease.^<11>C-diacylglycerol-PET studies in patients with cerebral infarction revealed hyperaccumlation in the prefrontal area in the subacute stage of cerebral infarction. The hyperaccumlation of ^<11>C-diacylglycerol in the prefrontal area in the subacute stage may indicate network plasticity in the cerebrum.Serial ^<18>F-fluorodopa-PET studies revealed hyperfunction of the presynaptic dopaminergic cells of the bilateral striatum in bobble-head doll syndrome. The suppression of output systems caused by hyperfunction of the presynaptic dopaminergic cells may play an important role of the occurrence of bobble-head doll movement.In the diffuse infiltrating tumor of the basal ganglia, ^<18>F-fluorodopa-PET study revealed that the presynaptic dopaminergic cells of the bilateral striatum were consistent within the tumor. In the expansive tumor such as metastatic tumors, ^<18>F-fluorodopa-PET showed accumulation of ^<18>F-fluorodopa in the striatum around the tumor. These results indicate that ^<18>F-fluorodopa-PET studies contribute to a qualitative diagnosis of the tumor in the basal ganglia.These PET data will be practical use for in vivo analysis of human basal ganglia and direct prediction of the network plasticity in the cerebrum.

基底节无疑是哺乳动物前脑中最复杂、最不被了解的结构之一。在本研究中，我们用正电子发射计算机断层扫描(PET)和氟多巴-正电子发射计算机断层扫描(PET)对基底神经节功能障碍患者治疗前后的脑组织磷脂酰肌醇代谢和基底节多巴胺代谢进行了研究。帕金森病患者治疗前后双侧纹状体磷脂酰肌醇代谢加速，同侧丘脑功能受抑。这些结果表明丘脑底核间接通路在帕金森病患者中的优越性。脑梗塞患者的~(11)&gt；C-二酰甘油-正电子发射计算机断层扫描显示脑梗塞亚急性期额叶前区过度蓄积。亚急性期前额叶区β&lt；11&gt；C-二酰甘油过度蓄积可能提示大脑网络可塑性。系列研究显示泡头娃娃综合征患者双侧纹状体突触前多巴胺能细胞功能亢进。突触前多巴胺能细胞功能亢进对输出系统的抑制可能在泡头娃娃运动的发生中起重要作用。在基底节弥漫性浸润性肿瘤中，~(18)F-F-氟代多巴-正电子发射计算机断层扫描显示双侧纹状体内突触前多巴胺能细胞在肿瘤内是一致的。在膨胀型肿瘤中，如转移性肿瘤，~(18)F-Folododa-PET显示肿瘤周围纹状体区有~~(18)F-Folodopa的聚集。这些结果表明，~(18)F-Folodopa-PET研究有助于对基底节肿瘤的定性诊断，这些PET数据将在活体分析人类基底节和直接预测大脑网络可塑性方面有实用价值。

项目成果

期刊论文数量（23）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

pterional approachの手術手技

翼点入路手术技术

DOI：
发表时间：
2005
期刊：
脳神経外科学大系.(山浦晶編)(東京,中山書店)
影响因子：
0
作者：
峯浦一喜;笹島浩泰;大和田敬
通讯作者：
大和田敬

Tractography for arteriovenous malformations near the sensorimotor cortices

感觉运动皮层附近动静脉畸形的纤维束成像

DOI：
发表时间：
2006
期刊：
AJNR Am J Neuroradiol 26(3)
影响因子：
0
作者：
Yamada K;Kizu O;Ito H;Kubota T;Akada W;Goto M;Takada A;Konishi J;Sasajima H;Mineura K;Mori S;Nishimura T
通讯作者：
Nishimura T

Occipital transtentorial approach for superior cerebellar tumors.

枕叶经小脑幕入路治疗小脑上肿瘤。