CHARACTERIZATION OF METAL LOST FROM MERCURY-CONTAINING DENTAL AMALGAMS BY XAS

通过 XAS 表征含汞牙科汞合金中损失的金属

• 批准号: 7722046
• 负责人: Satya Prakash Singh
• 金额: $ 0.31万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7722046
• 关键词: Age; Be++ element; Behavior; Beryllium; Chemicals; Computer Retrieval of Information on Scientific Projects Database; Condition; Dental Amalgam; Elements; Food; Funding; Grant; Health Hazards; Institution; Leeching; Mercury; Metals; Methylmercury Compounds; Mouthwash; Oral; Research; Research Personnel; Resources; Roentgen Rays; Saliva; Source; Spectrum Analysis; Toothpaste; United States National Institutes of Health; absorption; drinking; hazard; insight; molecular scale; restoration

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The use of dental amalgam as a direct restoration material has been controversial for several decades because of potential health hazards caused by leeching of metals and in particular of mercury. Some mercury forms (such as methylmercury species) are considerably more toxic than others (such as the elemental form). Thus, in order to help assess the potential hazards of dental amalgam, it is necessary to establish not only how much of a given element is leeched under various conditions, but also the element?s chemical form. In this proposed research, we plan to apply X-ray absorption spectroscopy (XAS) to study what chemical species may be released from dental amalgam of different ages under various treatments mimicking normal oral exposures such as pristine saliva, food and drink, toothpaste and mouthwash. Information obtained from this study will assist in understanding released metal toxicological behavior at the molecular scale, and will provide much-needed insights into the potential hazards or otherwise of the use of dental amalgam.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 几十年来，使用牙科汞合金作为直接修复材料一直存在争议，因为金属（特别是汞）的浸出会造成潜在的健康危害。某些汞形式（例如甲基汞）的毒性比其他形式（例如单质形式）要高得多。因此，为了帮助评估牙科用汞合金的潜在危害，不仅有必要确定在各种条件下有多少给定元素被浸出，而且还需要确定该元素的化学形式。在这项拟议的研究中，我们计划应用X射线吸收光谱（XAS）来研究不同年龄的牙科汞合金在模拟正常口腔接触（例如原始唾液、食物和饮料、牙膏和漱口水）的各种治疗下可能释放出哪些化学物质。从这项研究中获得的信息将有助于了解分子尺度上释放的金属毒理学行为，并将为使用牙科汞合金的潜在危害或其他方面提供急需的见解。