CHARACTERIZATION OF METAL LOST FROM MERCURY-CONTAINING DENTAL AMALGAMS BY XAS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 几十年来，使用牙科银汞合金作为直接修复材料一直存在争议，因为金属，特别是汞的浸出可能会对健康造成危害。某些汞形态(如甲基汞物种)比其他形态(如元素汞)毒性大得多。因此，为了帮助评估牙科汞齐的潜在危险，不仅需要确定在不同条件下特定元素的浸出量，而且还需要确定元素的S化学形式。在这项拟议的研究中，我们计划应用X射线吸收光谱(XAS)来研究不同年龄的银汞合金在模拟正常口腔暴露的不同处理下可能释放出哪些化学物种，如原始唾液、食物和饮料、牙膏和漱口水。从这项研究中获得的信息将有助于在分子水平上了解释放的金属毒理学行为，并将为使用牙科汞齐的潜在危险或其他方面提供亟需的见解。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The use of dental amalgam as a direct restoration material has been controversial for several decades because of potential health hazards caused by leeching of metals and in particular of mercury. Some mercury forms (such as methylmercury species) are considerably more toxic than others (such as the elemental form). Thus, in order to help assess the potential hazards of dental amalgam, it is necessary to establish not only how much of a given element is leeched under various conditions, but also the element?s chemical form. In this proposed research, we plan to apply X-ray absorption spectroscopy (XAS) to study what chemical species may be released from dental amalgam of different ages under various treatments mimicking normal oral exposures such as pristine saliva, food and drink, toothpaste and mouthwash. Information obtained from this study will assist in understanding released metal toxicological behavior at the molecular scale, and will provide much-needed insights into the potential hazards or otherwise of the use of dental amalgam.