CRYSTALLOGRAPHIC STUDIES OF KEY PROTEINS FROM GLOBAL INFECTIOUS DISEASES

全球传染病关键蛋白质的晶体学研究

• 批准号: 7721850
• 负责人: STEWART TURLEY
• 金额: $ 0.48万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7721850
• 关键词: Affinity; African Trypanosomiasis; Architecture; Biogenesis; Characteristics; Cholera; Cholera Toxin; Communicable Diseases; Complex; Computer Retrieval of Information on Scientific Projects Database; Development; Disease; Funding; Glycosome; Grant; Human; Institution; Laboratories; Leishmaniasis; Malaria; Membrane; Parasites; Pharmacologic Substance; Property; Proteins; RNA Editing; Research; Research Personnel; Resources; Source; System; Tuberculosis; United States National Institutes of Health; Vibrio cholerae; inhibitor/antagonist; insertion/deletion mutation; interest; novel; pathogen

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Hol laboratory is focused on proteins from major global pathogens that are promising targets for the development of much-needed new pharmaceuticals to treat such diseases as malaria, sleeping sickness, leishmaniasis, tuberculosis and cholera. A characteristic of the laboratory is to study proteins and in particular multi-proteins assemblies that are, by themselves, extremely interesting with respect to architecture, function and properties and then aim for novel ways to obtain high affinity inhibitors. As a result we are investigating mainly multi-protein assemblies, including cholera toxin in complex with human proteins, the unique U-insertion/deletion RNA editing system in Trypanosomatids, Peroxins involved in glycosome biogenesis, the invasion machinery of the malaria parasite, and the Type 2 Secretion System which exports cholera toxin across the outer membrane of Vibrio cholerae.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 HOL实验室的重点是来自主要全球病原体的蛋白质，这些蛋白质是开发急需的新药的有希望的靶标，以治疗诸如疟疾，睡眠疾病，利什曼病，结核病和霍乱等疾病。实验室的一个特征是研究蛋白质，特别是在建筑，功能和性质方面非常有趣的多蛋白质组件，然后旨在寻求新的方法来获得高亲和力抑制剂。 As a result we are investigating mainly multi-protein assemblies, including cholera toxin in complex with human proteins, the unique U-insertion/deletion RNA editing system in Trypanosomatids, Peroxins involved in glycosome biogenesis, the invasion machinery of the malaria parasite, and the Type 2 Secretion System which exports cholera toxin across the outer membrane of Vibrio cholerae.