DEVELOPMENT OF A BROADBAND TWO LAYER MODEL OF TISSUES

宽带两层组织模型的开发

• 批准号: 7722526
• 负责人: ALBERT Edward CERUSSI
• 金额: $ 3.85万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-15 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7722526
• 关键词: Algorithms; Computer Retrieval of Information on Scientific Projects Database; Development; Diffuse; Diffusion; Equation; Fourier Transform; Funding; Grant; Institution; Lipids; Measurement; Muscle; Optics; Property; Recovery; Reporting; Research; Research Personnel; Resources; Simulate; Solutions; Source; Testing; Thick; Time; Tissue Model; Tissues; United States National Institutes of Health; absorption; base; chromophore; simulation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The recovery of broadband (650nm~1000nm) diffuse optical spectra stratified by layer in a tissue-simulating, two-layer phantom is reported for the first time. The broadband optical properties of the phantom featured a top layer consistent with lipids and a bottom layer consistent with muscle. The concentrations of chromophores in both layers (top layer thickness greater than 5mm) were calculated from the recovered diffuse optical spectra with an average 15% error. The recovery is based on a Fourier transform solution to the diffusion equation using multi-distance broadband diffuse optical reflectance measurements. The algorithm recovers the absorption and reduced scattering coefficients in both layers and top layer thickness. This algorithm is insensitive to initial guesses of both layers' optical properties as long as the layer thickness initial guess is within ¿ 2mm. The robustness of the fitting routine is further tested with Monte Carlo simulations.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本文首次报道了在一个模拟组织的双层体模中，实现了宽带（650 nm ~ 1000 nm）漫反射光谱的分层恢复。体模的宽带光学特性具有与脂质一致的顶层和与肌肉一致的底层。从恢复的漫射光谱计算两个层（顶层厚度大于5 mm）中的发色团浓度，平均误差为15%。的恢复是基于傅里叶变换的解决方案的扩散方程，使用多距离宽带漫反射测量。该算法恢复了两层和顶层厚度中的吸收和约化散射系数。该算法对两个层的光学性质的初始猜测不敏感，只要层厚度初始猜测在± 2 mm内。拟合例程的鲁棒性进一步测试与Monte Carlo模拟。