COMPARISONS OF MRI AND DOS IN MEASUREMENTS OF BREAST DENSITY

MRI 和 DOS 在乳腺密度测量中的比较

• 批准号: 8362611
• 负责人: ALBERT Edward CERUSSI
• 金额: $ 2.07万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362611
• 关键词: Biotechnology; Breast; Funding; Goals; Grant; Hormonal; Image; Lasers; Lesion; Light; Magnetic Resonance Imaging; Measurement; Modeling; National Center for Research Resources; Physiological; Principal Investigator; Research; Research Infrastructure; Resources; Source; Techniques; Tissues; United States National Institutes of Health; breast density; cancer risk; cost; instrument; malignant breast neoplasm

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Mammographic breast density is known to contribute to breast cancer risk due to (a) additional hormonal exposer and physiological influence, and (b) obscuring of lesions. Little has been investigated as to how MRI breast density may compare with mammographic breast density. Even less is known about how DOS is influenced by specific MRI signatures in tissues. Using a dedicated DOS instrument on loan to the UCSF Breast imaging center, we have co-registered MRI and DOS measurements. The MRI was used to compute breast density as well as provide a 3D mesh for modeling of light transport in the breast. The goal is to understand both MRI and DOS better by combining techniques to reveal the origins of breast density.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 已知乳房X线摄影乳腺密度会增加乳腺癌风险，原因是（a）额外的激素分泌和生理影响，以及（B）病变模糊。 关于MRI乳腺密度与乳房X光检查乳腺密度的比较，人们几乎没有进行过研究。 关于DOS如何受到组织中特定MRI特征的影响，我们所知甚少。 我们使用租借给UCSF乳腺成像中心的专用DOS仪器，共同配准MRI和DOS测量。 MRI用于计算乳腺密度，并提供3D网格，用于模拟乳腺中的光传输。 我们的目标是通过结合技术来更好地了解MRI和DOS，以揭示乳腺密度的起源。