COMPARISONS OF MRI AND DOS IN MEASUREMENTS OF BREAST DENSITY

MRI 和 DOS 在乳腺密度测量中的比较

• 批准号: 8362611
• 负责人: ALBERT Edward CERUSSI
• 金额: $ 2.07万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362611
• 关键词: Biotechnology; Breast; Funding; Goals; Grant; Hormonal; Image; Lasers; Lesion; Light; Magnetic Resonance Imaging; Measurement; Modeling; National Center for Research Resources; Physiological; Principal Investigator; Research; Research Infrastructure; Resources; Source; Techniques; Tissues; United States National Institutes of Health; breast density; cancer risk; cost; instrument; malignant breast neoplasm

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Mammographic breast density is known to contribute to breast cancer risk due to (a) additional hormonal exposer and physiological influence, and (b) obscuring of lesions. Little has been investigated as to how MRI breast density may compare with mammographic breast density. Even less is known about how DOS is influenced by specific MRI signatures in tissues. Using a dedicated DOS instrument on loan to the UCSF Breast imaging center, we have co-registered MRI and DOS measurements. The MRI was used to compute breast density as well as provide a 3D mesh for modeling of light transport in the breast. The goal is to understand both MRI and DOS better by combining techniques to reveal the origins of breast density.

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