PHYSIOLOGICAL SIGNATURE OF CACHEXIA FOR DETECTION AND THERAPUTIC MONITORING

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的目的是测量和表征恶病质肌肉组织的生理特性，使用宽带漫反射光谱（DOS）。 恶病质是一种组织在没有积极尝试减肥的情况下浪费的情况，并且发生在某些特定类型癌症的患者中。 为了了解如何更好地诊断和治疗恶病质，我们必须首先了解组织消耗背后的机制。 这是一个plot研究，第一个同类研究，调查恶病质肌肉组织的特定生理特征。 目标是（1）改善恶病质诊断，和（B）监测组织对治疗干预的反应

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this research study is to measure and characterize the physiological properties of cachexic muscle tissues using broadband diffuse optical spectroscopy (DOS). Cachexia is the condition where tissues waste away without an active attempt to loose weight, and occurs in some patients with specific types of cancer. In order to understand how to better diagnose and treat cachexia, we must first understand the mechanisms behind the wasting away of tissues. This is a pliot study, the first of its kind, to investiage specific physiological signatures of cachexic muscle tissues. the goal will be to (1) improve diagnoisis of cachexia, and (b) monitor response of tissues to theraputic intervention