SYNTHESIS OF MARINE DERIVED MACROCYCLIC SALICYLATES

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Research in our laboratory focuses on the synthesis of complex molecular architectures; in particular naturally occurring substances with novel structural features and interesting biological function. Unpredictable and unique chemical reactivity patterns oftentimes encountered during the assembly of a particular natural product target continues to challenge synthetic chemists. Taking advantage of the research environment at UT Southwestern, we are increasingly integrating molecular pharmacology and biochemical aspects into our research program.