Chemistry and Cancer Scientific Program
化学和癌症科学计划
基本信息
- 批准号:10260734
- 负责人:
- 金额:$ 3.22万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-08-03 至 2021-07-31
- 项目状态:已结题
- 来源:
- 关键词:AgonistBiochemicalBiologicalBiologyCancer CenterCancer Center Support GrantCancer cell lineChemicalsChemistryDissectionDrug resistanceFundingGeneticHumanHypoxiaMalignant NeoplasmsMedical centerMolecularMolecular TargetNCI-Designated Cancer CenterPathway interactionsPeer ReviewPharmaceutical PreparationsPhaseProcessPublicationsRegulationResearch InstituteResearch PersonnelScientistStructural BiologistTestingTexasToxincancer cellcancer preventioncrosslinkcytotoxicdesigndrug discoveryinter-institutionalinterestmembernovelpreclinical developmentprogramsresistance mechanismresponsesmall molecule
项目摘要
Harold C. Simmons Cancer Center
Chemistry and Cancer Scientific Program
Project Summary/Abstract
The Chemistry and Cancer (CC) Program combines the expertise of synthetic and medicinal chemists,
molecular biologists, biochemists, structural biologists, and clinician scientists to discover, design, and optimize
drug-like small molecules that regulate biological pathways deregulated in cancer. There are a total of 16
members who are drawn from 4 departments on campus. CC's discovery process takes a two-pronged
approach, starting from a chemistry-to-biology or a biology-to-chemistry direction. For the chemistry-to-biology
approach, the discovery process starts with identifying natural or unnatural small molecules that are selectively
cytotoxic to human cancer cell lines, followed by a rigorous target identification program. During this “discovery
biology” phase, chemists design specific derivatives to aid in biochemical pull-down and cross-linking studies.
Or, if specific drug-resistant clones against the small molecule of interest can be generated, genetic and
molecular biological studies can provide additional approaches to identify target pathways and/or drug
resistance mechanisms. This unbiased approach is expected to identify novel cancer-specific pathways that
can be chemically interrogated/regulated for proof-of-concept, early drug-discovery efforts. In the biology-to-
chemistry approach, hypotheses regarding the “drugability” and cancer relevance of specific biological
pathways investigated by Simmons Cancer Center scientists can be tested with small-molecule agonists or
antagonists.
The CC Scientific Program will continue broadly with the following themes:
· Theme 1. Identifying the molecular targets of cancer cell–specific small-molecule toxins;
· Theme 2. Biochemical dissection of novel, cancer cell–specific pathways;
· Theme 3. Proof-of-concept preclinical development of cancer cell–specific small-molecule toxins; and
· Theme 4. Dissection, regulation, and targeting of the hypoxia response pathway.
Current peer-reviewed funding for the CC Program is highlighted by $1.5 million from the NCI and $2.8 million
from Cancer Prevention and Research Institute of Texas for total peer-reviewed funding of $7.1 million. CC
Program members have authored 103 peer-reviewed publications since 2009, of which 19% were intra-
programmatic and 30% inter-programmatic, and 15% of them inter-institutional with investigators from other
NCI-designated cancer centers.
哈罗德·西蒙斯癌症中心
化学与癌症科学计划
项目摘要/摘要
化学与癌症(CC)计划结合了合成化学家和药物化学家的专业知识,
分子生物学家、生物化学家、结构生物学家和临床科学家来发现、设计和优化
类药物小分子,调节在癌症中放松调控的生物途径。一共有16个
来自校园内4个部门的成员。CC的发现过程双管齐下
方法,从化学到生物或从生物到化学的方向。从化学到生物
方法,发现过程开始于识别有选择性的天然或非天然小分子
对人类癌细胞系具有细胞毒性,随后进行严格的靶标识别程序。在这个“发现”过程中
在“生物学”阶段,化学家设计了特定的衍生品,以帮助进行生化下拉和交联性研究。
或者,如果可以产生针对目标小分子的特定抗药性克隆,遗传和
分子生物学研究可以提供更多的方法来识别靶途径和/或药物
抗性机制。这种不偏不倚的方法有望识别新的癌症特异性途径,
可以对其进行化学讯问/管制,以进行概念验证和早期药物发现工作。在生物学上-到-
化学方法,关于特定生物的“可药性”和癌症相关性的假设
西蒙斯癌症中心科学家研究的通路可以用小分子激动剂或
对抗者。
CC科学计划将继续广泛开展以下主题:
·主题1.确定癌细胞特异性小分子毒素的分子靶标;
·主题2.对新的癌细胞特有途径的生化剖析;
·主题3.针对癌细胞的小分子毒素的概念验证临床前开发;以及
·主题4.低氧反应途径的解剖、调节和靶向。
目前经同行审查的CC计划资金主要来自NCI的150万美元和280万美元
来自德克萨斯州癌症预防和研究所的同行评审资金总额为710万美元。抄送
自2009年以来,计划成员已经撰写了103份同行评议的出版物,其中19%是内部审查的-
方案和30%的方案间,其中15%是机构间的,有来自其他机构的调查人员
NCI指定的癌症中心。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('JEF KAREL DE BRABANDER', 18)}}的其他基金
Structural elucidation and development of agonists for the human orexin receptors
人类食欲素受体激动剂的结构阐明和开发
- 批准号:
9751989 - 财政年份:2017
- 资助金额:
$ 3.22万 - 项目类别:
Structural elucidation and development of agonists for the human orexin receptors
人类食欲素受体激动剂的结构阐明和开发
- 批准号:
9513162 - 财政年份:2017
- 资助金额:
$ 3.22万 - 项目类别:
Structural elucidation and development of agonists for the human orexin receptors
人类食欲素受体激动剂的结构阐明和开发
- 批准号:
10241919 - 财政年份:2017
- 资助金额:
$ 3.22万 - 项目类别:
Development of Small Molecule Orexin Receptor Agonists for Treating Narcolepsy
治疗发作性睡病的小分子食欲素受体激动剂的开发
- 批准号:
7829541 - 财政年份:2009
- 资助金额:
$ 3.22万 - 项目类别:
Development of Small Molecule Orexin Receptor Agonists for Treating Narcolepsy
治疗发作性睡病的小分子食欲素受体激动剂的开发
- 批准号:
7937840 - 财政年份:2009
- 资助金额:
$ 3.22万 - 项目类别:
SYNTHESIS OF MARINE DERIVED MACROCYCLIC SALICYLATES
海洋衍生大环水杨酸盐的合成
- 批准号:
7721420 - 财政年份:2008
- 资助金额:
$ 3.22万 - 项目类别:
Identifying the Molecular Targets of Novel Cytotoxic Agents
识别新型细胞毒剂的分子靶点
- 批准号:
7315650 - 财政年份:2007
- 资助金额:
$ 3.22万 - 项目类别:
SYNTHESIS OF MARINE DERIVED MACROCYCLIC SALICYLATES
海洋衍生大环水杨酸盐的合成
- 批准号:
7355164 - 财政年份:2006
- 资助金额:
$ 3.22万 - 项目类别:
SYNTHESIS OF MARINE DERIVED MACROCYCLIC SALICYLATES
海洋衍生大环水杨酸盐的合成
- 批准号:
7180058 - 财政年份:2005
- 资助金额:
$ 3.22万 - 项目类别:
SYNTHESIS OF MARINE DERIVED MACROCYCLIC SALICYLATES
海洋衍生大环水杨酸盐的合成
- 批准号:
6977025 - 财政年份:2003
- 资助金额:
$ 3.22万 - 项目类别:
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