MR1 BIOCHEMICAL FEATURES AND IMMUNOLOGICAL FUNCTIONS

MR1 生化特征和免疫功能

• 批准号: 7721485
• 负责人: TED Howard HANSEN
• 金额: $ 0.05万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-02-01 至 2009-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7721485
• 关键词: Biochemical; Class; Collaborations; Computer Retrieval of Information on Scientific Projects Database; Development; Funding; Grant; Institution; Mammals; Mucosal Immunity; Population; Proteins; Research; Research Personnel; Resources; Source; Structure; T-Cell Receptor; T-Lymphocyte; Transgenic Organisms; United States National Institutes of Health; novel; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. What is the function of the novel class-I-like protein, MR1, in regulating mucosal immunity? MR1 is highly conserved MHC-I-like protein in mammals, that activates a unique population of T cells with an invariant T cell receptor. Interestingly the development of these MR1 activated T cells is dependent upon the commensal flora of the gut. Our experiments are using biochemical, cellular, transgenic and crystallographic approaches to determine the structure and function of MR1 proteins. MS is one of the approaches that represents a cross-campus and cross-resource collaboration.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 新型I类蛋白MR1在调节粘膜免疫方面有何功能？ MR1 是哺乳动物中高度保守的 MHC-I 样蛋白，可激活具有不变 T 细胞受体的独特 T 细胞群。有趣的是，这些 MR1 激活的 T 细胞的发育取决于肠道的共生菌群。我们的实验使用生化、细胞、转基因和晶体学方法来确定 MR1 蛋白的结构和功能。 MS 是代表跨校园、跨资源协作的方法之一。