QUANTITATION OF DMSO BY GC/EI/MS IN MAMMALIAN CNS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 项目概述：多种溶剂杀死发育中的哺乳动物中枢神经系统中的神经元。溶剂包括DMSO、丙二醇、聚乙二醇（PEG）、甲醇和壬醇。在表征大脑的特定区域和产生损伤所需的剂量之后，需要确定脑组织中药剂的浓度，以便帮助确定对人类婴儿的潜在意义。将通过GC/EI/MS进行鉴别和定量。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Project Summary: A wide range of solvents kill neurons in the developing mammalian CNS. Solvents include DMSO, propylene glycol, polyethylene glycol(PEG), methanol and nonanol. After characterizing the specific regions of the brain and the doses needed to produce the damage, concentrations of the agents in brain tissue need to be determined in order in order to help determine the potential significance to human infants. Identification and quantitation will be carried out by GC/EI/MS.