QUANTITATION OF DMSO BY GC/EI/MS IN MAMMALIAN CNS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 项目摘要：广泛的溶剂可以杀死发育中的哺乳动物中枢神经系统中的神经元。溶剂包括二甲基亚砜、丙二醇、聚乙二醇酯、甲醇和正庚醇。在确定了大脑的特定区域和造成损害所需的剂量后，需要测定脑组织中这些药物的浓度，以便帮助确定对人类婴儿的潜在意义。将通过GC/EI/MS进行鉴定和定量。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Project Summary: A wide range of solvents kill neurons in the developing mammalian CNS. Solvents include DMSO, propylene glycol, polyethylene glycol(PEG), methanol and nonanol. After characterizing the specific regions of the brain and the doses needed to produce the damage, concentrations of the agents in brain tissue need to be determined in order in order to help determine the potential significance to human infants. Identification and quantitation will be carried out by GC/EI/MS.