GENOMIC AND METABOLOMIC FOUNDATIONS OF HUMAN-MICROBIAL SYMBIOSIS IN THE GUT

肠道中人类-微生物共生的基因组学和代谢组学基础

• 批准号: 7721558
• 负责人: JEFFREY I GORDON
• 金额: $ 2.25万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-02-01 至 2009-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7721558
• 关键词: Acetates; Biological Markers; Butyrates; Computer Retrieval of Information on Scientific Projects Database; Dietary Polysaccharide; Foundations; Funding; Genomics; Grant; Human; Institution; Measures; Metabolism; Mus; Propionates; Research; Research Personnel; Resources; Sampling; Source; Structure; Symbiosis; United States National Institutes of Health; Volatile Fatty Acids; butyrate; metabolomics; microbial; microbial community; microbiome

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Project Summary: We are attempting to correlate the structure of the gut microbial community and its microbiome with its metabolome. Measuring levels of short chain fatty acids (acetate, butyrate, propionate) provides us with a biomarker of dietary polysaccharide metabolism by the microbiota. Levels to be measured by GC-MS in samples of cecal contents obtained from genotobiotic mice

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 项目摘要：我们正在尝试将肠道微生物群落及其微生物群的结构与其代谢组相关联。通过测定短链脂肪酸(醋酸盐、丁酸盐、丙酸)的水平，我们可以通过微生物区系来了解饮食中多糖的代谢。用气相色谱-质谱法测定遗传生物小鼠盲肠内容物样品中的含量