GENOMIC AND METABOLOMIC FOUNDATIONS OF HUMAN-MICROBIAL SYMBIOSIS IN THE GUT

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 项目摘要：我们正在尝试将肠道微生物群落的结构及其微生物组与其代谢组关联起来。测量短链脂肪酸（乙酸盐、丁酸盐、丙酸盐）的水平为我们提供了微生物群代谢膳食多糖的生物标志物。通过 GC-MS 测量从基因细菌小鼠获得的盲肠内容物样品中的水平

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Project Summary: We are attempting to correlate the structure of the gut microbial community and its microbiome with its metabolome. Measuring levels of short chain fatty acids (acetate, butyrate, propionate) provides us with a biomarker of dietary polysaccharide metabolism by the microbiota. Levels to be measured by GC-MS in samples of cecal contents obtained from genotobiotic mice