ANALYSIS OF YEAST MITOCHONDRIAL DNA STABILITY BY DAPI STAINING

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这个项目的目标是寻找和鉴定导致遗传性听力障碍的基因。DFNA15为POU4F3，DFNB30为MYO3A，DFNB28为Tara的新亚型。在这个项目的下一个周期中，我们的目标包括通过在扩展的家系中进行位置克隆来识别隐性和显性听力损失的基因，无论是否有综合症特征。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this project is to find and characterize genes responsible for hereditary hearing impairment. We have previously identified DFNA15 as POU4F3, DFNB30 as MYO3A, and DFNB28 as a novel isoform of TARA. In the next cycle of this project, our goals include identification of genes for recessive and dominant hearing loss, with or without syndromic features, by positional cloning in extended kindreds.