ANALYSIS OF YEAST MITOCHONDRIAL DNA STABILITY BY DAPI STAINING

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this project is to find and characterize genes responsible for hereditary hearing impairment. We have previously identified DFNA15 as POU4F3, DFNB30 as MYO3A, and DFNB28 as a novel isoform of TARA. In the next cycle of this project, our goals include identification of genes for recessive and dominant hearing loss, with or without syndromic features, by positional cloning in extended kindreds.